GLIMSER 2MG 15

About

Glimepiride is an oral sulfonylurea antidiabetic agent used in the management of type 2 diabetes mellitus. It primarily works by stimulating the beta cells of the pancreas to release insulin. This action is glucose-dependent, meaning insulin secretion is increased when blood glucose levels are high. Glimepiride also has some extrapancreatic effects, such as increasing the sensitivity of peripheral tissues to insulin and reducing hepatic glucose production. It is typically prescribed when diet and exercise alone are insufficient to control blood sugar levels, or as an adjunct to other antidiabetic medications. As a potent insulin secretagogue, it effectively lowers fasting and postprandial glucose, contributing to a significant reduction in HbA1c. Its mechanism helps improve overall glycemic control, but careful dosing and consistent monitoring of blood glucose levels are essential to minimize the risk of hypoglycemia, a common side effect associated with sulfonylureas.

Uses

• Management of type 2 diabetes mellitus.
• Lowering blood glucose levels.
• As an adjunct to diet and exercise.
• Can be used in combination with other antidiabetic agents.

Directions For Use

Take orally once daily with the first main meal of the day, as directed by your physician.

Benefits

• Effective in lowering blood glucose.
• Reduces HbA1c levels.
• Stimulates insulin secretion.
• Convenient once-daily dosing.
• Well-established efficacy.
• Can be used in combination therapy.

Side Effects

• Hypoglycemia
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Allergic skin reactions
• Weight gain
• Visual disturbances
• Liver enzyme elevation
• Leukopenia (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can potentiate the hypoglycemic effect of glimepiride and may cause a disulfiram-like reaction.
• Pregnancy - Not recommended during pregnancy due to potential for fetal hypoglycemia. Insulin is generally preferred for glycemic control in pregnant women.
• Breastfeeding - Glimepiride may be excreted in breast milk and could cause hypoglycemia in the infant. Breastfeeding is generally not recommended.
• Liver - Use with caution in patients with hepatic impairment as it can increase the risk of hypoglycemia and drug accumulation.
• Kidney - Use with caution in patients with renal impairment. Dose adjustment may be necessary to avoid accumulation and increased risk of hypoglycemia.
• Lung - No specific contraindications related to lung conditions. However, severe illness can affect glucose levels, requiring careful monitoring.

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