GLUFORMIN G2 FORTE 10'S

About

This medication is a fixed-dose combination of two established oral antidiabetic agents: Metformin and Glimepiride. Metformin, a biguanide, primarily acts by reducing hepatic glucose production and enhancing insulin sensitivity in peripheral tissues, thereby improving glucose uptake and utilization. Glimepiride, a sulfonylurea, stimulates the beta cells of the pancreas to release more insulin, particularly in response to meals. This synergistic dual mechanism of action provides comprehensive and potent glycemic control for adults with type 2 diabetes mellitus, especially when monotherapy with either agent or diet and exercise alone are insufficient to achieve target blood glucose levels. The "Forte" designation typically indicates a higher strength, offering enhanced efficacy in managing significantly elevated blood glucose and HbA1c levels, helping to prevent long-term diabetes complications.

Uses

• Treatment of type 2 diabetes mellitus.
• Improvement of glycemic control.
• When diet and exercise are insufficient.
• As an adjunct to lifestyle modifications.

Directions For Use

Take orally with meals to reduce gastrointestinal side effects. Follow your doctor's prescribed dosage and frequency.

Benefits

• Provides dual-action blood sugar control.
• Effectively lowers HbA1c levels.
• Improves insulin sensitivity.
• Reduces hepatic glucose production.
• Convenient combination therapy.
• Helps manage hyperglycemia.

Side Effects

• Hypoglycemia
• Nausea
• Diarrhea
• Abdominal discomfort
• Metallic taste
• Headache
• Dizziness
• Weight gain (due to glimepiride)
• Lactic acidosis (rare, with metformin)
• Vitamin B12 deficiency (with metformin)
• Skin rash
• Photosensitivity

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis, especially with metformin.
• Pregnancy - Generally not recommended during pregnancy; insulin therapy is often preferred for glycemic control in pregnant women with diabetes.
• Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk and could cause hypoglycemia in the infant.
• Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis (metformin) and prolonged drug effects (glimepiride).
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to the risk of metformin accumulation and lactic acidosis.
• Lung - Use with caution in conditions causing hypoxia (e.g., severe respiratory failure) as it may increase the risk of lactic acidosis.

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