About
Metffil VG Tab is a combination medication containing Metformin and Vildagliptin, used in the management of type 2 diabetes mellitus. Metformin, a biguanide, primarily works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity by enhancing peripheral glucose uptake and utilization. Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the levels of active incretin hormones (GLP-1 and GIP). These incretins stimulate insulin release from pancreatic beta cells and suppress glucagon secretion from alpha cells in a glucose-dependent manner, thereby improving glycemic control.
This dual mechanism of action provides comprehensive blood glucose lowering effects, addressing multiple pathophysiological defects in type 2 diabetes. The combination is particularly effective for patients whose blood sugar is not adequately controlled with metformin monotherapy or who require a synergistic approach to achieve target HbA1c levels. It helps to reduce both fasting and post-prandial glucose levels, contributing to better overall metabolic management.
Uses
- Management of type 2 diabetes mellitus.
- As an adjunct to diet and exercise.
- When metformin monotherapy is insufficient.
- To improve glycemic control in adults.
Directions For Use
Take orally with meals to minimize gastrointestinal side effects. Follow your doctor's prescribed dosage and schedule.
Benefits
- Provides effective glycemic control.
- Reduces both fasting and post-meal blood sugar.
- Lowers HbA1c levels significantly.
- Offers a dual mechanism of action.
- Generally well-tolerated.
- May have a low risk of hypoglycemia.
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Metallic taste
- Headache
- Dizziness
- Nasopharyngitis
- Tremor
- Fatigue
- Hypoglycemia (rare)
- Lactic acidosis (rare, serious)
Safety Measures
- Alcohol - Avoid excessive alcohol intake due to an increased risk of lactic acidosis, especially with metformin.
- Pregnancy - Generally not recommended during pregnancy unless the potential benefits outweigh the risks. Consult your doctor.
- Breastfeeding - Metformin passes into breast milk; vildagliptin data is limited. Consult a healthcare professional before use.
- Liver - Use with caution; metformin is contraindicated in severe hepatic impairment. Vildagliptin is not recommended in moderate to severe impairment.
- Kidney - Dose adjustment is required; contraindicated in severe renal impairment due to metformin accumulation and increased risk of lactic acidosis.
- Lung - No specific contraindication, but caution is advised in severe respiratory conditions that may increase the risk of acidosis.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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