GLUFORMIN G1 FORTE 10S

About

Gluformin G1 Forte is a combination oral antidiabetic medication containing Metformin and Glimepiride 1mg, used for the management of Type 2 diabetes mellitus. Metformin, a biguanide, works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity. Glimepiride, a sulfonylurea, stimulates insulin release from pancreatic beta cells. This dual-action approach provides comprehensive glycemic control, particularly when monotherapy with either agent is insufficient. The "Forte" designation may indicate a higher strength of Metformin or an extended-release formulation, designed to optimize blood sugar regulation throughout the day and reduce the risk of diabetes-related complications.

Uses

• Management of Type 2 diabetes mellitus
• When diet and exercise are insufficient
• Improving glycemic control in adults
• Reducing fasting and post-meal glucose levels

Directions For Use

Take one tablet orally, usually once or twice daily with meals, as prescribed by your healthcare provider.

Benefits

• Dual mechanism for comprehensive glucose control
• Reduces hepatic glucose production
• Enhances insulin sensitivity and secretion
• Helps achieve target HbA1c levels
• May lead to modest weight loss (Metformin)
• Reduces risk of long-term diabetes complications

Side Effects

• Hypoglycemia (low blood sugar)
• Gastrointestinal upset (nausea, diarrhea)
• Abdominal pain or discomfort
• Metallic taste in mouth
• Headache
• Dizziness
• Lactic acidosis (rare but serious)
• Vitamin B12 deficiency with long-term use
• Skin rash or itching
• Weight gain (less common than with sulfonylureas alone)
• Anemia
• Photosensitivity

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to increased risk of hypoglycemia and lactic acidosis, especially with Metformin.
• Pregnancy - Not recommended during pregnancy; insulin is generally preferred. Consult your doctor immediately if pregnant or planning pregnancy.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk. Consult your doctor.
• Liver - Contraindicated in severe liver impairment due to increased risk of lactic acidosis with Metformin. Use with extreme caution.
• Kidney - Contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73m²) due to risk of lactic acidosis. Dose adjustment needed for moderate impairment.
• Lung - Use with caution in severe lung conditions (e.g., severe COPD, acute respiratory failure) due to increased risk of lactic acidosis.

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