About
Voglibose 0.3mg and Metformin is a combination medication used to manage type 2 diabetes mellitus. Voglibose is an alpha-glucosidase inhibitor that works by delaying the digestion and absorption of carbohydrates from the intestine, thereby reducing the post-meal rise in blood glucose levels. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization.
This dual mechanism of action helps achieve better glycemic control, especially in patients whose blood sugar levels are not adequately controlled by diet, exercise, or monotherapy. The combination targets different pathways involved in glucose metabolism, offering a comprehensive approach to managing hyperglycemia and preventing long-term diabetic complications. It is typically prescribed as an adjunct to lifestyle modifications.
Uses
- Management of type 2 diabetes mellitus.
- To improve glycemic control in adults.
- When diet and exercise alone are insufficient.
- As an adjunct to other antidiabetic therapies.
Directions For Use
Take this medication orally with meals, as directed by your physician. Swallow the tablet whole with water.
Benefits
- Effectively lowers post-meal blood sugar.
- Reduces overall HbA1c levels.
- Improves insulin sensitivity.
- Helps prevent long-term diabetic complications.
- May contribute to modest weight loss (Metformin).
- Offers a dual mechanism of action for comprehensive control.
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Flatulence
- Indigestion
- Headache
- Dizziness
- Metallic taste in mouth
- Vitamin B12 deficiency
- Lactic acidosis (rare but serious)
- Hypoglycemia (especially with other agents)
- Skin rash
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, especially with Metformin, and may affect blood sugar levels.
- Pregnancy - Generally not recommended during pregnancy unless clearly necessary and benefits outweigh risks. Consult a doctor.
- Breastfeeding - Metformin passes into breast milk; Voglibose data is limited. Consult a doctor to weigh risks and benefits.
- Liver - Use with caution in patients with liver impairment; Metformin is contraindicated in severe hepatic dysfunction due to increased lactic acidosis risk.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to Metformin accumulation and increased lactic acidosis risk. Dose adjustment may be needed for moderate impairment.
- Lung - No specific contraindications related to lung conditions, but severe respiratory failure can increase lactic acidosis risk.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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