GLUFORMIN G 1 10

About

Gluformin G 1 is an oral combination medication prescribed for the management of Type 2 diabetes mellitus, featuring Metformin and Glimepiride 1mg. Metformin, a biguanide, primarily acts by reducing glucose production in the liver and improving the body's sensitivity to insulin, leading to better glucose uptake by cells. Glimepiride, a sulfonylurea, stimulates the pancreas to release more insulin. This synergistic action helps to effectively lower both fasting and post-meal blood glucose levels, providing comprehensive control over hyperglycemia. It is typically used when diet, exercise, and monotherapy with either Metformin or Glimepiride are insufficient to achieve desired glycemic targets, thereby helping to prevent long-term diabetic complications.

Uses

• Treatment of Type 2 diabetes mellitus
• When diet and exercise are inadequate
• To improve glycemic control in adults
• Reducing both fasting and postprandial glucose

Directions For Use

Take one tablet orally, usually once or twice daily with meals, or as directed by your healthcare professional.

Benefits

• Combines two effective antidiabetic agents
• Provides comprehensive blood sugar control
• Reduces hepatic glucose output
• Enhances insulin secretion and sensitivity
• Helps achieve target HbA1c levels
• Contributes to preventing diabetes complications

Side Effects

• Hypoglycemia (low blood sugar)
• Gastrointestinal disturbances (nausea, diarrhea)
• Abdominal discomfort or bloating
• Metallic taste in the mouth
• Headache
• Dizziness
• Lactic acidosis (rare, serious)
• Vitamin B12 deficiency with prolonged use
• Skin reactions (rash, itching)
• Weight gain (less common than with sulfonylureas alone)
• Anemia
• Photosensitivity

Safety Measures

• Alcohol - Avoid excessive alcohol intake due to increased risk of hypoglycemia and lactic acidosis, especially with Metformin.
• Pregnancy - Not recommended during pregnancy; insulin is generally the preferred treatment. Consult your doctor if pregnant or planning.
• Breastfeeding - Not recommended during breastfeeding as active ingredients may pass into breast milk. Consult your doctor.
• Liver - Contraindicated in severe liver impairment due to the risk of lactic acidosis associated with Metformin. Use with extreme caution.
• Kidney - Contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73m²) due to risk of lactic acidosis. Dose adjustment needed for moderate impairment.
• Lung - Use with caution in severe lung conditions (e.g., severe COPD, acute respiratory failure) due to increased risk of lactic acidosis.

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