About
This medication combines a dipeptidyl peptidase-4 (DPP-4) inhibitor with metformin hydrochloride, offering a dual mechanism of action for the management of type 2 diabetes mellitus. The DPP-4 inhibitor works by increasing the levels of incretin hormones, which stimulate insulin release from the pancreas in a glucose-dependent manner and reduce glucagon secretion, thereby lowering blood glucose. Metformin, a biguanide, primarily reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. This synergistic combination helps achieve better glycemic control, particularly in patients whose blood sugar is not adequately controlled by metformin alone or by a DPP-4 inhibitor alone. It is an important therapeutic option for improving HbA1c levels and managing postprandial glucose excursions.
Uses
- Management of type 2 diabetes mellitus.
- Improvement of glycemic control in adults.
- Used when diet and exercise alone are insufficient.
- As an add-on therapy to other antidiabetic agents.
Directions For Use
Take orally with meals, usually once or twice daily, as directed by your physician. Swallow the tablet whole with water.
Benefits
- Improved glycemic control.
- Reduced HbA1c levels.
- Dual mechanism of action.
- Lower risk of hypoglycemia compared to sulfonylureas.
- May aid in weight management (Metformin component).
- Convenient fixed-dose combination.
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- Upper respiratory tract infection
- Nasopharyngitis
- Hypoglycemia (especially with other antidiabetics)
- Lactic acidosis (rare, Metformin)
- Pancreatitis (rare, DPP-4 inhibitor)
- Joint pain
- Skin reactions
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a rare but serious side effect of metformin.
- Pregnancy - Generally not recommended during pregnancy unless clearly necessary, as data on human pregnancy is limited. Consult your doctor.
- Breastfeeding - Metformin is excreted in breast milk; the DPP-4 inhibitor component may also be. Use with caution and under medical supervision.
- Liver - Use with caution in patients with hepatic impairment; metformin is contraindicated in severe liver disease due to increased risk of lactic acidosis.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment may be required for moderate impairment.
- Lung - No specific contraindications related to lung conditions, but severe acute respiratory failure can increase lactic acidosis risk.
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!