About
FPGLI M2 Forte Tab is likely a combination medication containing Glimepiride and Metformin, used for the management of type 2 diabetes mellitus in adults. Glimepiride, a sulfonylurea, stimulates insulin release from pancreatic beta cells, thereby lowering blood glucose. Metformin, a biguanide, reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues.
This dual-action approach provides comprehensive glycemic control, addressing different aspects of type 2 diabetes pathophysiology. It is typically prescribed when diet and exercise, along with monotherapy with either glimepiride or metformin, are insufficient to achieve adequate glycemic targets. The combination helps to reduce HbA1c levels more effectively than either agent alone. Patients should be educated on the risk of hypoglycemia, especially when initiating therapy or adjusting doses.
Uses
- To improve glycemic control in adults with type 2 diabetes mellitus.
- As an adjunct to diet and exercise.
- When monotherapy with glimepiride or metformin is inadequate.
- To reduce the risk of diabetes-related complications.
Directions For Use
Take orally once or twice daily with meals, as directed by your physician, to minimize gastrointestinal side effects.
Benefits
- Provides synergistic blood glucose lowering.
- Effectively reduces HbA1c levels.
- Combines two established antidiabetic mechanisms.
- May lead to modest weight loss (due to metformin).
- Improves both insulin secretion and sensitivity.
- Convenient combination therapy.
Side Effects
- Hypoglycemia (low blood sugar)
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Metallic taste in mouth
- Headache
- Dizziness
- Lactic acidosis (rare, but serious)
- Vitamin B12 deficiency
- Allergic skin reactions
- Weight gain (less common than with sulfonylurea alone)
Safety Measures
- Alcohol - Avoid excessive alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis.
- Pregnancy - Not recommended during pregnancy due to potential for fetal hypoglycemia and insufficient data for metformin.
- Breastfeeding - Not recommended during breastfeeding as both components can pass into breast milk.
- Liver - Contraindicated in severe liver impairment due to increased risk of lactic acidosis with metformin.
- Kidney - Contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73 m²); dose adjustments are crucial for moderate impairment.
- Lung - Generally safe, but acute/chronic lung disease with hypoxia can increase lactic acidosis risk with metformin.
Disclaimer
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