About
Tucatinib is a highly selective tyrosine kinase inhibitor (TKI) specifically designed to target the human epidermal growth factor receptor 2 (HER2) and HER3 pathways. It is primarily used in combination with other agents for the treatment of advanced HER2-positive breast cancer, particularly in patients who have previously received multiple anti-HER2 therapies. Tucatinib works by reversibly binding to the intracellular kinase domain of HER2, thereby inhibiting HER2 phosphorylation and downstream signaling pathways that drive cancer cell growth and survival.
Its selectivity for HER2 minimizes off-target effects, and its ability to cross the blood-brain barrier makes it particularly valuable for treating brain metastases, a common complication in HER2-positive breast cancer.
Uses
- Advanced HER2-positive breast cancer
- Metastatic HER2-positive breast cancer
- HER2-positive breast cancer with brain metastases
- In combination with trastuzumab and capecitabine
Directions For Use
Take orally twice daily, approximately 12 hours apart, with or without food. Swallow tablets whole; do not chew, crush, or split.
Benefits
- Highly selective HER2 inhibitor.
- Effective in advanced HER2+ breast cancer.
- Demonstrated efficacy against brain metastases.
- Improves progression-free survival.
- Can be combined with other anti-HER2 agents.
- Offers a new treatment option for refractory disease.
Side Effects
- Diarrhea
- Nausea
- Fatigue
- Vomiting
- Stomatitis
- Hand-foot syndrome
- Elevated liver enzymes (AST/ALT)
- Rash
- Anemia
- Headache
- Abdominal pain
- Decreased appetite
Safety Measures
- Alcohol - No specific contraindication, but alcohol may exacerbate gastrointestinal side effects. Discuss with your doctor.
- Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Effective contraception is required for women of childbearing potential.
- Breastfeeding - Not recommended during breastfeeding due to potential for serious adverse effects in the infant.
- Liver - Use with caution and dose reduction in patients with moderate to severe hepatic impairment. Monitor liver function closely.
- Kidney - No specific dose adjustment is typically required for mild to moderate renal impairment. Use with caution in severe impairment.
- Lung - Generally safe for use in patients with lung conditions. Monitor for rare interstitial lung disease.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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