About
Ursodeoxycholic acid (UDCA) is a naturally occurring bile acid that works by reducing the amount of cholesterol produced by the liver and absorbed by the gut. It helps to dissolve cholesterol gallstones and is also used in the treatment of certain liver diseases where bile flow is impaired. Its mechanism involves altering the composition of bile, making it less lithogenic (stone-forming) and protecting liver cells from toxic bile acids. It also has immunomodulatory properties, contributing to its therapeutic effects in cholestatic liver conditions.
This medication is crucial for patients with specific hepatobiliary disorders, aiming to improve bile flow, reduce inflammation, and prevent further damage to liver cells. Its efficacy is well-established in conditions like primary biliary cholangitis and for the dissolution of small to medium-sized cholesterol gallstones in patients who are not candidates for surgery.
Uses
- Dissolution of cholesterol gallstones.
- Treatment of primary biliary cholangitis (PBC).
- Management of cholestatic liver diseases.
- Prevention of gallstone formation in rapid weight loss.
Directions For Use
Take this medication orally, usually with food, as directed by your physician. Do not crush or chew the tablets.
Benefits
- Dissolves certain types of cholesterol gallstones.
- Improves liver function in cholestatic conditions.
- Reduces symptoms associated with primary biliary cholangitis.
- Protects liver cells from damage by toxic bile acids.
- May prevent gallstone recurrence after successful dissolution.
- Generally well-tolerated with a long safety record.
Side Effects
- Diarrhea
- Nausea
- Abdominal pain
- Constipation
- Indigestion
- Vomiting
- Rash
- Itching
- Hair thinning
- Dizziness
- Fatigue
- Allergic reactions (rare)
Safety Measures
- Alcohol - Avoid or limit alcohol consumption as it can worsen liver conditions and potentially interact with the medication.
- Pregnancy - Use with caution; consult a doctor. Animal studies show potential harm, but human data is limited.
- Breastfeeding - Generally considered safe, but consult a healthcare professional before use.
- Liver - Used to treat liver conditions, but caution is advised in severe liver failure.
- Kidney - Generally safe for use in patients with kidney conditions; no dose adjustment typically needed.
- Lung - No specific contraindications or precautions related to lung conditions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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