Xtane 25mg Tablet

About

Xtane 25mg Tablet contains Exemestane, an irreversible steroidal aromatase inactivator, primarily indicated for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. This medication plays a crucial role in endocrine therapy by effectively reducing estrogen levels in the body. In postmenopausal women, the primary source of estrogen is the conversion of androgens into estrogens by the aromatase enzyme, which is found in peripheral tissues, including fat, muscle, and breast cancer cells.

Exemestane works by binding permanently to the active site of the aromatase enzyme, thereby inactivating it and preventing the synthesis of estrogen. By significantly lowering circulating estrogen, Xtane deprives estrogen-sensitive breast cancer cells of the growth stimulus they require, thus inhibiting tumor proliferation and progression. It is often prescribed as adjuvant therapy following tamoxifen treatment or as a first-line treatment for advanced breast cancer, offering a vital therapeutic option to improve disease-free survival and overall outcomes for eligible patients.

Uses

• Adjuvant treatment of early breast cancer
• Treatment of advanced breast cancer
• Hormone-receptor-positive breast cancer
• Postmenopausal women with breast cancer

Directions For Use

Take one tablet orally once daily after a meal.

Benefits

• Reduces risk of breast cancer recurrence.
• Effective in hormone-sensitive tumors.
• Improves disease-free survival.
• Well-tolerated in many patients.
• Oral administration for convenience.
• Alternative for tamoxifen-resistant cases.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Headache
• Nausea
• Insomnia
• Increased sweating
• Bone thinning (osteoporosis)
• Vaginal dryness
• Hair thinning
• Depression
• Peripheral edema

Safety Measures

• Alcohol - Moderate alcohol intake is generally acceptable, but excessive use may exacerbate liver-related side effects.
• Pregnancy - Contraindicated in premenopausal women and during pregnancy due to potential fetal harm.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and affect the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary.
• Kidney - No specific dose adjustment required for mild to moderate renal impairment; use with caution in severe cases.
• Lung - No specific contraindications related to lung conditions.

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