Zoladex LA 10.8mg Injection

About

Goserelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH), designed for sustained release. Its mechanism of action involves a biphasic effect on the pituitary gland. Initially, it causes a transient surge in the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which can lead to a temporary increase in sex hormone levels (testosterone in men, estrogen in women). However, continuous administration of goserelin leads to the desensitization and downregulation of GnRH receptors in the pituitary. This sustained suppression results in a significant and prolonged reduction of LH and FSH secretion, consequently lowering sex hormone levels to castration levels. The 10.8mg formulation is a long-acting depot injection, administered every 12 weeks, providing consistent and profound hormonal suppression. This makes it an invaluable therapeutic option for hormone-sensitive cancers, such as advanced prostate and breast cancer, as well as other conditions benefiting from sex hormone reduction.

Uses

• Prostate cancer (advanced)
• Breast cancer (hormone-receptor positive, pre/perimenopausal)
• Endometriosis
• Uterine fibroids

Directions For Use

Administered subcutaneously into the abdominal wall by a healthcare professional every 12 weeks.

Benefits

• Sustained suppression of sex hormones.
• Effective in hormone-sensitive cancers.
• Long-acting formulation reduces injection frequency.
• Non-surgical alternative to castration.
• Reduces tumor growth and progression.
• Manages symptoms associated with endometriosis and fibroids.

Side Effects

• Hot flashes
• Decreased libido
• Erectile dysfunction (men)
• Vaginal dryness (women)
• Bone mineral density loss (long-term use)
• Injection site reactions (pain, bruising)
• Mood changes, depression
• Headache
• Sweating
• Breast tenderness/swelling (men)
• Weight gain
• Initial tumor flare (transient)

Safety Measures

• Alcohol - No specific contraindication, but moderation is generally advised.
• Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may interfere with infant hormone levels.
• Liver - Use with caution in patients with severe hepatic impairment; no specific dose adjustment usually needed.
• Kidney - No dose adjustment typically required for renal impairment.
• Lung - No specific lung-related safety concerns; monitor for general adverse effects.

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