Zoladex 3.6mg Injection

About

Goserelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH), formulated for controlled release. Its therapeutic action involves a dual effect on the pituitary gland. Initially, it stimulates the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which can cause a temporary increase in sex hormone levels (testosterone in men, estrogen in women). However, with continuous administration, goserelin induces desensitization and downregulation of the GnRH receptors in the pituitary. This sustained exposure leads to a profound and consistent suppression of LH and FSH secretion, effectively reducing sex hormone levels to castration levels. The 3.6mg formulation is a short-acting depot injection, administered every 28 days (4 weeks), ensuring continuous hormonal suppression. This makes it a critical therapeutic agent for managing hormone-dependent conditions, including advanced prostate cancer, hormone-receptor positive breast cancer in pre/perimenopausal women, endometriosis, and uterine fibroids, where reducing sex hormone levels is therapeutically beneficial.

Uses

• Prostate cancer (advanced)
• Breast cancer (hormone-receptor positive, pre/perimenopausal)
• Endometriosis
• Uterine fibroids

Directions For Use

Administered subcutaneously into the abdominal wall by a healthcare professional every 28 days.

Benefits

• Effective in achieving sex hormone suppression.
• Treats hormone-sensitive cancers and gynecological conditions.
• Provides a non-surgical alternative to castration.
• Reduces tumor burden and disease progression.
• Manages symptoms like pain in endometriosis.
• Well-established safety and efficacy profile.

Side Effects

• Hot flashes
• Decreased libido
• Erectile dysfunction (men)
• Vaginal dryness (women)
• Bone mineral density loss (long-term use)
• Injection site reactions (pain, bruising)
• Mood changes, depression
• Headache
• Sweating
• Breast tenderness/swelling (men)
• Weight gain
• Initial tumor flare (transient)

Safety Measures

• Alcohol - No specific contraindication, but moderation is generally advised.
• Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may interfere with infant hormone levels.
• Liver - Use with caution in patients with severe hepatic impairment; no specific dose adjustment usually needed.
• Kidney - No dose adjustment typically required for renal impairment.
• Lung - No specific lung-related safety concerns; monitor for general adverse effects.

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