Paleno 100mg Capsule

About

Paleno 100mg Capsule contains palbociclib, a targeted therapy classified as a cyclin-dependent kinase (CDK) 4 and 6 inhibitor. This medication works by selectively blocking the activity of CDK4 and CDK6 enzymes, which play a critical role in regulating cell cycle progression, particularly in the G1 phase. In many cancer cells, these kinases are overactive, leading to uncontrolled proliferation. By inhibiting CDK4/6, palbociclib arrests the cell cycle, preventing cancer cells from dividing and ultimately leading to their death. This mechanism makes it highly effective in treating hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer.

Paleno 100mg Capsule is typically administered in combination with endocrine therapy, such as an aromatase inhibitor or fulvestrant. Its synergistic action with these agents helps to overcome resistance mechanisms often seen with endocrine therapy alone, thereby enhancing treatment efficacy and improving patient outcomes. Clinical studies have demonstrated that palbociclib significantly prolongs progression-free survival in eligible patients, establishing it as a cornerstone in the management of advanced HR+/HER2- breast cancer.

Uses

• Treatment of HR+/HER2- advanced or metastatic breast cancer.
• Used in combination with an aromatase inhibitor as initial endocrine-based therapy.
• Used in combination with fulvestrant after disease progression on prior endocrine therapy.
• To delay disease progression and improve survival in eligible patients.

Directions For Use

Take orally once daily with food for 21 consecutive days, followed by 7 days off, to complete a 28-day cycle. Swallow the capsule whole; do not chew, crush, or open.

Benefits

• Significantly improves progression-free survival in advanced breast cancer.
• Enhances the efficacy of endocrine therapy when used in combination.
• Offers a targeted treatment approach for specific breast cancer subtypes.
• Can delay the need for cytotoxic chemotherapy in some patients.
• Improves overall response rates when combined with other agents.
• Provides a valuable option for patients with HR+/HER2- metastatic disease.

Side Effects

• Neutropenia (low white blood cell count)
• Leukopenia (low total white blood cell count)
• Fatigue
• Nausea
• Diarrhea
• Stomatitis (mouth sores)
• Hair thinning or loss (alopecia)
• Infections
• Anemia (low red blood cell count)
• Thrombocytopenia (low platelet count)
• Rash
• Abnormal liver function tests

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects like nausea or fatigue, and could potentially interact with the medication's metabolism.
• Pregnancy - Paleno 100mg Capsule can cause fetal harm. Women of childbearing potential must use effective contraception during treatment and for at least 3 weeks after the last dose.
• Breastfeeding - It is unknown if palbociclib is excreted in human milk. Due to the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended during treatment and for 3 weeks after the last dose.
• Liver - Use with caution in patients with moderate to severe hepatic impairment, as dose adjustments may be necessary due to altered drug metabolism.
• Kidney - Use with caution in patients with severe renal impairment, as dose adjustments may be required due to potential changes in drug clearance.
• Lung - Monitor for signs and symptoms of interstitial lung disease (ILD) or pneumonitis, such as dyspnea, cough, and fever, and interrupt treatment if suspected.

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