Eltrog 25mg Tablet

About

Eltrombopag is an orally active, non-peptide thrombopoietin receptor agonist that plays a vital role in stimulating the production of platelets. It specifically binds to the thrombopoietin receptor (TPO-R) on the surface of megakaryocytes and their progenitor cells in the bone marrow, initiating intracellular signaling cascades that promote the proliferation and differentiation of megakaryocytes. This process ultimately leads to a significant increase in platelet production. This mechanism is particularly beneficial for patients suffering from conditions characterized by critically low platelet counts, such as chronic immune thrombocytopenia (ITP), severe aplastic anemia (SAA), and thrombocytopenia associated with chronic hepatitis C virus infection, where maintaining adequate platelet levels is crucial to prevent life-threatening bleeding episodes and improve overall patient outcomes.

Uses

• Chronic immune thrombocytopenia (ITP).
• Severe aplastic anemia (SAA).
• Thrombocytopenia in chronic hepatitis C virus infection.
• To increase platelet counts in patients at risk of bleeding.

Directions For Use

Take orally once daily on an empty stomach, at least 2 hours before or 4 hours after consuming calcium-containing products.

Benefits

• Increases platelet counts effectively.
• Reduces the risk of bleeding events.
• Allows for dose reduction or discontinuation of other ITP treatments.
• Improves quality of life for patients with chronic ITP.
• Offers an oral treatment option.
• Supports hematopoietic recovery in SAA.

Side Effects

• Nausea
• Diarrhea
• Upper respiratory tract infection
• Fatigue
• Fever
• Cough
• Abdominal pain
• Headache
• Myalgia (muscle pain)
• Arthralgia (joint pain)
• Increased liver enzymes
• Thromboembolic events (rare but serious)

Safety Measures

• Alcohol - No specific interaction, but excessive alcohol can affect liver function, which is important to monitor with this medication.
• Pregnancy - Not recommended during pregnancy due to potential for fetal harm. Use effective contraception during treatment.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it is excreted in human milk and could harm the infant.
• Liver - Contraindicated in severe hepatic impairment for ITP. Close monitoring of liver function is essential for all indications; dose adjustments may be needed.
• Kidney - Use with caution in patients with renal impairment; no specific dose adjustment guidelines, but monitor renal function.
• Lung - No specific contraindications related to lung conditions.

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