Acalaside 100mg Capsule

About

Acalaside is a highly selective and potent Bruton's tyrosine kinase (BTK) inhibitor, representing a class of targeted therapies crucial for the treatment of specific B-cell malignancies. It functions by forming a covalent bond with a cysteine residue in the BTK active site, leading to irreversible inhibition of the enzyme. BTK is a critical component of the B-cell receptor signaling pathway, which is essential for the survival, proliferation, and migration of malignant B-lymphocytes. By effectively inhibiting BTK, Acalaside disrupts these aberrant signaling pathways, thereby inducing apoptosis and reducing the tumor burden in conditions such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). This targeted oral therapy offers a significant advantage by providing a more precise mechanism of action compared to traditional chemotherapy.

Uses

• Treatment of chronic lymphocytic leukemia (CLL).
• Treatment of small lymphocytic lymphoma (SLL).
• Management of mantle cell lymphoma (MCL).
• Used in patients who have received at least one prior therapy.

Directions For Use

Take orally as directed by your physician, usually twice daily, with or without food. Swallow the capsule whole.

Benefits

• Targeted inhibition of BTK.
• Effective in specific B-cell malignancies.
• Oral administration convenience.
• Improved progression-free survival.
• May offer an alternative to chemotherapy.
• Generally well-tolerated compared to some other treatments.

Side Effects

• Headache
• Diarrhea
• Fatigue
• Myalgia (muscle pain)
• Bruising
• Nausea
• Rash
• Anemia
• Neutropenia (low white blood cells)
• Thrombocytopenia (low platelets)
• Upper respiratory tract infection
• Hypertension

Safety Measures

• Alcohol - Limit alcohol consumption as it may exacerbate certain side effects like headache or gastrointestinal upset.
• Pregnancy - Acalaside is not recommended during pregnancy due to potential fetal harm. Effective contraception should be used by women of reproductive potential.
• Breastfeeding - Due to the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended during Acalaside treatment and for a period after the last dose.
• Liver - Use with caution in patients with pre-existing liver impairment. Dose adjustments may be necessary, and liver function should be monitored.
• Kidney - No specific dose adjustment is typically required for mild to moderate renal impairment, but caution is advised in severe cases.
• Lung - Monitor for new or worsening pulmonary symptoms, as rare cases of pneumonitis have been reported with BTK inhibitors.

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