Acogenib 250mg Tablet

About

Acogenib 250mg Tablet is a targeted therapy, specifically a tyrosine kinase inhibitor (TKI), used in the treatment of certain cancers characterized by specific genetic mutations. It works by selectively blocking aberrant signaling pathways that are crucial for cancer cell growth, proliferation, and survival, such as those involving epidermal growth factor receptor (EGFR) or other relevant kinases. By inhibiting these specific tyrosine kinases, Acogenib effectively disrupts the molecular mechanisms driving tumor progression, leading to reduced tumor size and inhibited metastatic spread. This precision medicine approach allows for a more focused attack on cancer cells, often resulting in a more favorable side effect profile compared to conventional chemotherapy. It represents a significant advancement in personalized cancer treatment for patients with specific genetic mutations, improving progression-free survival and overall outcomes.

Uses

• Treatment of non-small cell lung cancer (NSCLC) with specific mutations.
• Management of chronic myeloid leukemia (CML).
• Therapy for gastrointestinal stromal tumors (GIST).
• Treatment of renal cell carcinoma.

Directions For Use

Take one tablet orally once daily, with or without food, as directed by an oncologist.

Benefits

• Targeted action with potentially fewer systemic side effects.
• Effective in specific patient populations with mutations.
• Convenient oral administration.
• Can improve progression-free survival.
• May lead to durable responses.
• Contributes to a better quality of life.

Side Effects

• Skin rash (acneiform dermatitis).
• Diarrhea.
• Fatigue.
• Nausea and vomiting.
• Elevated liver enzymes.
• Interstitial lung disease (rare but serious).
• Fluid retention (edema).
• Hypertension (high blood pressure).
• Hand-foot syndrome.
• Stomatitis (mouth sores).
• Headache.
• Abdominal pain.

Safety Measures

• Alcohol - Avoid or limit consumption, as it can exacerbate liver toxicity and gastrointestinal side effects associated with the medication.
• Pregnancy - Contraindicated, as it can cause fetal harm and is associated with teratogenic effects.
• Breastfeeding - Contraindicated, as the drug passes into breast milk and can cause serious adverse effects in the infant.
• Liver - Use with caution; monitor liver function closely, and dosage adjustment may be required in hepatic impairment.
• Kidney - Use with caution; monitor renal function, and dosage adjustment may be required in severe renal impairment.
• Lung - Use with extreme caution; monitor for new or worsening pulmonary symptoms due to the risk of interstitial lung disease.

Disclaimer

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