About

Doxorubicin is an anthracycline topoisomerase inhibitor widely utilized in chemotherapy for its potent cytotoxic effects. Its mechanism of action involves multiple pathways, primarily by intercalating into DNA, inhibiting topoisomerase II, and generating reactive oxygen species. These actions lead to DNA damage, disruption of DNA replication and repair, and ultimately induce apoptosis in rapidly dividing cancer cells. Doxorubicin is effective against a broad spectrum of solid tumors and hematologic malignancies, making it a cornerstone in various combination chemotherapy regimens. While highly effective, its use requires careful management due to potential for significant adverse effects, notably dose-dependent cardiotoxicity, myelosuppression, and mucositis. Patient monitoring for cardiac function and hematologic parameters is crucial throughout the treatment course to mitigate risks and optimize therapeutic outcomes.

Uses

Acute lymphoblastic leukemia
Hodgkin's and non-Hodgkin's lymphoma
Breast cancer
Ovarian cancer

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency are determined by the patient's condition and treatment protocol.

Benefits

Broad-spectrum anticancer activity
Effective in various solid tumors
Induces tumor regression
Part of established chemotherapy regimens
Improves survival rates in certain cancers
Targets rapidly dividing cells

Side Effects

Myelosuppression (neutropenia, thrombocytopenia)
Cardiotoxicity (dose-dependent)
Nausea and vomiting
Alopecia (hair loss)
Mucositis/stomatitis
Red urine (harmless)
Extravasation injury
Fatigue
Anorexia
Hyperpigmentation of skin/nails
Secondary malignancies
Arrhythmias

Safety Measures

Alcohol - Avoid alcohol due to potential for increased liver toxicity and gastrointestinal irritation, especially during chemotherapy.
Pregnancy - Contraindicated in pregnancy due to severe fetal harm and teratogenicity. Effective contraception is essential.
Breastfeeding - Not recommended during breastfeeding as doxorubicin is excreted in breast milk and can cause serious adverse effects in the infant.
Liver - Use with extreme caution; dosage adjustments are necessary in patients with hepatic impairment due to impaired drug clearance and increased toxicity risk.
Kidney - Generally safe in mild to moderate renal impairment, but close monitoring is advised. Severe renal impairment may require dose adjustments.
Lung - While not a primary lung toxicant, patients with pre-existing lung conditions should be monitored for any respiratory distress, especially if other cardiotoxic agents are co-administered.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.

Shipping & Location