About
Atorvastatin is a potent lipid-lowering agent belonging to the statin class, specifically an HMG-CoA reductase inhibitor. It works by competitively inhibiting the enzyme HMG-CoA reductase, which is crucial for cholesterol synthesis in the liver. This inhibition leads to a reduction in hepatic cholesterol production, which in turn upregulates LDL receptors on liver cells, increasing the clearance of LDL-cholesterol from the bloodstream. Atorvastatin effectively lowers elevated total cholesterol, LDL-cholesterol, and triglycerides, while also increasing high-density lipoprotein (HDL-cholesterol) levels. It is widely prescribed for the primary and secondary prevention of cardiovascular events, including myocardial infarction and stroke, in patients with hyperlipidemia or those at high cardiovascular risk. Beyond its lipid-lowering effects, atorvastatin also possesses pleiotropic effects, such as anti-inflammatory and plaque-stabilizing properties, contributing to its overall cardiovascular benefits. Regular monitoring of lipid profiles and liver function tests is recommended during therapy to ensure safety and efficacy.
Uses
- Reduction of elevated total cholesterol and LDL-cholesterol.
- Treatment of primary hypercholesterolemia and mixed dyslipidemia.
- Primary prevention of cardiovascular events in high-risk patients.
- Secondary prevention of myocardial infarction and stroke.
Directions For Use
Take one tablet orally once daily, at any time of day, with or without food, as directed by your physician.
Benefits
- Significantly lowers "bad" cholesterol (LDL-C).
- Reduces triglyceride levels.
- Increases "good" cholesterol (HDL-C).
- Decreases the risk of heart attack and stroke.
- Slows the progression of atherosclerosis.
- Provides comprehensive cardiovascular protection.
Side Effects
- Muscle pain (myalgia)
- Joint pain (arthralgia)
- Diarrhea
- Nausea
- Headache
- Fatigue
- Insomnia
- Abdominal pain
- Indigestion
- Elevated liver enzymes
- Nasopharyngitis
- Urinary tract infection
Safety Measures
- Alcohol - Excessive alcohol consumption can increase the risk of liver problems associated with statins. Limit intake.
- Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Women of childbearing potential should use effective contraception.
- Breastfeeding - Contraindicated during breastfeeding as it may be excreted in milk and cause adverse effects in the infant.
- Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Monitor liver function.
- Kidney - Generally safe in renal impairment; no dosage adjustment is typically required.
- Lung - No specific contraindications or major concerns related to lung conditions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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