Akynzeo Injection

About

Akynzeo (Netupitant/Palonosetron) is a fixed-dose combination antiemetic medication specifically formulated for the prevention of both acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy, as well as moderately emetogenic cancer chemotherapy. This innovative therapy combines two distinct antiemetic agents: a neurokinin-1 (NK1) receptor antagonist (netupitant) and a serotonin-3 (5-HT3) receptor antagonist (palonosetron). By targeting two separate, critical pathways involved in chemotherapy-induced nausea and vomiting (CINV), Akynzeo provides comprehensive and sustained protection. The NK1 receptor antagonist component helps prevent delayed CINV, while the 5-HT3 receptor antagonist addresses acute CINV. This dual mechanism significantly improves patient comfort, reduces the burden of emetic symptoms, and enhances adherence to crucial chemotherapy regimens. It is conveniently administered intravenously as a single dose prior to the start of chemotherapy, offering a proactive and effective solution for managing this common and distressing side effect of cancer treatment.

Uses

• Prevention of acute chemotherapy-induced nausea.
• Prevention of delayed chemotherapy-induced vomiting.
• Used with highly emetogenic chemotherapy.
• Used with moderately emetogenic chemotherapy.

Directions For Use

Administered intravenously by a healthcare professional approximately 30 minutes before the start of chemotherapy.

Benefits

• Provides dual antiemetic action.
• Effective against both acute and delayed CINV.
• Significantly reduces nausea and vomiting.
• Improves patient comfort during chemotherapy.
• Enhances adherence to cancer treatment.
• Convenient single-dose administration.

Side Effects

• Headache
• Constipation
• Fatigue
• Dizziness
• Dyspepsia
• Bradycardia (slow heart rate)
• Hypokalemia (low potassium)
• Injection site reactions
• Hiccups
• Diarrhea
• Abdominal pain
• Insomnia

Safety Measures

• Alcohol - Alcohol consumption is generally not recommended during chemotherapy treatment. Consult your doctor.
• Pregnancy - Use only if clearly needed and the potential benefit justifies the potential risk to the fetus. Discuss with your doctor.
• Breastfeeding - It is not known if components are excreted in human milk. Exercise caution and consult your doctor.
• Liver - No dose adjustment is needed for mild to moderate hepatic impairment. Use with caution in severe impairment.
• Kidney - No dose adjustment is needed for mild to moderate renal impairment. Use with caution in severe impairment.
• Lung - Generally safe for use in patients with lung conditions. No specific precautions are usually required.

Disclaimer

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