About

Abiraterone acetate is an oral androgen biosynthesis inhibitor primarily used in the treatment of advanced prostate cancer. It functions by selectively and irreversibly inhibiting cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), a key enzyme expressed in testicular, adrenal, and prostatic tumor tissues. This enzyme is essential for the biosynthesis of androgens, which are hormones that stimulate the growth of prostate cancer cells. By blocking CYP17, abiraterone significantly reduces the production of androgens throughout the body, thereby slowing the progression of hormone-sensitive and castration-resistant prostate cancer. It is typically prescribed in conjunction with a corticosteroid, such as prednisone, to mitigate potential side effects related to mineralocorticoid excess, ensuring a more tolerable and effective treatment regimen for patients battling this aggressive disease.

Uses

Treatment of metastatic castration-resistant prostate cancer (mCRPC).
Treatment of metastatic high-risk castration-sensitive prostate cancer (mCSPC).
Used in men who have not received prior chemotherapy for mCRPC.
Used in men whose disease has progressed after prior chemotherapy.

Directions For Use

Take orally once daily on an empty stomach, at least one hour before or two hours after food. Swallow tablets whole with water.

Benefits

Prolongs overall survival in mCRPC patients.
Delays disease progression.
Reduces prostate-specific antigen (PSA) levels.
Improves quality of life for some patients.
Offers a non-chemotherapy option for advanced prostate cancer.
Can be used in combination with prednisone to manage side effects.

Side Effects

Fatigue
Joint pain/swelling
Hot flashes
Diarrhea
Nausea
Vomiting
Peripheral edema
Hypertension
Hypokalemia
Liver enzyme elevation
Urinary tract infection
Anemia

Safety Measures

Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver side effects and increase the risk of adverse reactions.
Pregnancy - Contraindicated in pregnant women; can cause fetal harm. Women of childbearing potential should avoid contact with crushed or broken tablets.
Breastfeeding - Not applicable for male patients. For female caregivers, avoid contact with the drug and consult a healthcare professional.
Liver - Use with caution in patients with pre-existing liver impairment; regular liver function monitoring is essential due to potential hepatotoxicity.
Kidney - Generally safe in mild to moderate renal impairment; no dose adjustment needed. Use with caution and monitor in severe impairment.
Lung - No specific contraindications related to lung conditions, but monitor for any new or worsening respiratory symptoms.

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