Xbira 250mg Tablet

About

Xbira 250mg Tablet, containing Abiraterone Acetate, is an androgen biosynthesis inhibitor prescribed for the management of metastatic castration-resistant prostate cancer (mCRPC) and high-risk metastatic hormone-sensitive prostate cancer. Its therapeutic action is centered on the potent and selective inhibition of the cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17) enzyme. This enzyme plays a pivotal role in the biosynthesis of androgens, not only in the testes and adrenal glands but also within the prostate tumor itself, which can continue to produce its own androgens even after conventional castration.

By effectively blocking CYP17, Abiraterone significantly reduces systemic and intratumoral androgen levels, thereby depriving prostate cancer cells of the growth stimuli they depend on. This mechanism helps to halt or slow the progression of the disease. The 250mg formulation allows for flexible dosing, typically prescribed as four tablets (1000mg total) once daily, always in conjunction with a low-dose corticosteroid such as prednisone or prednisolone to mitigate potential side effects related to mineralocorticoid excess. This oral therapy represents a cornerstone in the treatment strategy for advanced prostate cancer.

Uses

• Metastatic castration-resistant prostate cancer
• High-risk metastatic hormone-sensitive prostate cancer
• In combination with prednisone/prednisolone
• Androgen deprivation therapy

Directions For Use

Take four tablets (1000mg total) orally once daily on an empty stomach. Do not crush or chew.

Benefits

• Extends overall survival in mCRPC.
• Delays disease progression.
• Reduces prostate-specific antigen (PSA) levels.
• Oral administration for convenience.
• Effective in hormone-refractory cases.
• Improves quality of life.

Side Effects

• Fluid retention (edema)
• Hypertension
• Hypokalemia
• Fatigue
• Joint swelling/discomfort
• Hot flashes
• Diarrhea
• Urinary tract infection
• Elevated liver enzymes
• Cardiac disorders (e.g., atrial fibrillation)
• Adrenal insufficiency
• Hypertriglyceridemia

Safety Measures

• Alcohol - Avoid excessive alcohol, as it may increase the risk of liver toxicity.
• Pregnancy - Contraindicated in women who are or may become pregnant due to potential fetal harm.
• Breastfeeding - Not applicable for male patients; women should not breastfeed if exposed.
• Liver - Use with extreme caution in patients with moderate to severe liver impairment; dose adjustments are necessary.
• Kidney - No dose adjustment required for mild to moderate renal impairment; use with caution in severe cases.
• Lung - No specific contraindications related to lung conditions, but general monitoring is advised.

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