Ahabir 500mg Tablet

About

Abiraterone, often known by brand names like Ahabir, is a potent androgen biosynthesis inhibitor that specifically targets the cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17) enzyme. This crucial enzyme is expressed in testicular, adrenal, and prostatic tumor tissues and plays a pivotal role in the production of androgens. By inhibiting CYP17, abiraterone effectively prevents the synthesis of androgens, including testosterone, which are known to fuel the growth and progression of prostate cancer cells. This mechanism makes it a highly effective treatment for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC), significantly reducing systemic androgen levels. It is typically administered orally and is often prescribed in conjunction with prednisone to mitigate potential mineralocorticoid excess side effects, thereby improving therapeutic efficacy and patient tolerability.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC)
• Metastatic high-risk castration-sensitive prostate cancer (mCSPC)
• Prostate cancer progression after androgen deprivation therapy
• Hormone-sensitive prostate cancer

Directions For Use

Take orally once daily on an empty stomach, at least one hour before or two hours after food. Always take with prednisone as prescribed by your doctor.

Benefits

• Significantly prolongs overall survival in mCRPC.
• Delays disease progression in prostate cancer.
• Reduces androgen production throughout the body.
• Offers an effective oral treatment option.
• Improves quality of life for patients.
• Can be used in both pre- and post-chemotherapy settings.

Side Effects

• Fatigue
• Joint swelling/discomfort
• Hot flashes
• Diarrhea
• Hypertension
• Hypokalemia
• Fluid retention
• Liver enzyme elevation
• Urinary tract infection
• Peripheral edema
• Cardiac disorders (e.g., atrial fibrillation)
• Adrenal insufficiency (when discontinuing prednisone)

Safety Measures

• Alcohol - Limit alcohol intake as it may contribute to liver strain, a potential side effect of Abiraterone. Discuss with your doctor.
• Pregnancy - Abiraterone is contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing potential should avoid contact with crushed or broken tablets.
• Breastfeeding - Not applicable for male patients. For female caregivers, avoid breastfeeding due to potential drug excretion in milk and harm to the infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Regular monitoring of liver function tests is essential, and dose adjustments may be required.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment, as data are limited.
• Lung - No specific lung-related safety notes are typically associated with Abiraterone. However, general monitoring for any new or worsening symptoms is always advised.

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