Xbira 500mg Tablet

About

Xbira 500mg Tablet contains Abiraterone Acetate, a highly effective androgen biosynthesis inhibitor used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) and high-risk metastatic hormone-sensitive prostate cancer. This medication works by targeting and irreversibly inhibiting cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), an enzyme critical for androgen production. CYP17 is expressed in the testes, adrenal glands, and within prostate tumor cells themselves, making it a key enzyme in the synthesis of androgens.

By blocking CYP17, Abiraterone significantly reduces the production of androgens, including testosterone, which are essential for the growth and proliferation of prostate cancer cells. This reduction in androgen levels helps to slow disease progression and improve patient outcomes. Xbira is typically administered orally, usually in combination with a corticosteroid like prednisone or prednisolone, to manage potential mineralocorticoid excess side effects. Its introduction has significantly advanced the therapeutic landscape for advanced prostate cancer, offering a crucial option for patients whose disease has progressed despite conventional androgen deprivation therapy.

Uses

• Metastatic castration-resistant prostate cancer
• High-risk metastatic hormone-sensitive prostate cancer
• In combination with prednisone/prednisolone
• Androgen deprivation therapy

Directions For Use

Take four tablets (500mg total) orally once daily on an empty stomach. Do not crush or chew.

Benefits

• Extends overall survival in mCRPC.
• Delays disease progression.
• Reduces prostate-specific antigen (PSA) levels.
• Oral administration for convenience.
• Effective in hormone-refractory cases.
• Improves quality of life.

Side Effects

• Fluid retention (edema)
• Hypertension
• Hypokalemia
• Fatigue
• Joint swelling/discomfort
• Hot flashes
• Diarrhea
• Urinary tract infection
• Elevated liver enzymes
• Cardiac disorders (e.g., atrial fibrillation)
• Adrenal insufficiency
• Hypertriglyceridemia

Safety Measures

• Alcohol - Avoid excessive alcohol, as it may increase the risk of liver toxicity.
• Pregnancy - Contraindicated in women who are or may become pregnant due to potential fetal harm.
• Breastfeeding - Not applicable for male patients; women should not breastfeed if exposed.
• Liver - Use with extreme caution in patients with moderate to severe liver impairment; dose adjustments are necessary.
• Kidney - No dose adjustment required for mild to moderate renal impairment; use with caution in severe cases.
• Lung - No specific contraindications related to lung conditions, but general monitoring is advised.

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