Votrient 400mg Tablet

About

Votrient 400mg Tablet contains Pazopanib, a multi-targeted receptor tyrosine kinase inhibitor used in oncology. It works by blocking several pathways involved in tumor growth and angiogenesis, including vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-Kit. This targeted action helps to inhibit the proliferation of tumor cells and reduce the formation of new blood vessels that supply the tumor, thereby slowing disease progression. It is primarily indicated for the treatment of advanced renal cell carcinoma and advanced soft tissue sarcoma. Its mechanism offers a strategic approach to cancer therapy by disrupting critical signaling pathways essential for tumor survival and metastasis.

Uses

• Treats advanced renal cell carcinoma
• Manages advanced soft tissue sarcoma
• Used in certain ovarian cancers (off-label)
• Investigational for other solid tumors

Directions For Use

Take this tablet orally, usually once daily, at least one hour before or two hours after a meal. Swallow whole with water.

Benefits

• Effectively inhibits tumor growth
• Reduces tumor size in specific cancers
• Prolongs progression-free survival
• Targets multiple cancer pathways
• Offers oral administration convenience
• Improves patient outcomes in indicated cancers

Side Effects

• Fatigue
• Nausea
• Diarrhea
• Vomiting
• Hypertension
• Hair color changes
• Anorexia
• Headache
• Liver dysfunction
• Thrombocytopenia
• Proteinuria
• Hand-foot syndrome

Safety Measures

• Alcohol - Avoid or limit alcohol as it may exacerbate liver toxicity, a known and serious side effect of this medication.
• Pregnancy - Contraindicated during pregnancy due to potential for severe fetal harm; effective contraception is mandatory for women of childbearing potential.
• Breastfeeding - Not recommended during breastfeeding due to potential for serious adverse reactions in the infant from drug excretion into milk.
• Liver - Requires careful monitoring of liver function tests; dose adjustment or interruption may be necessary in hepatic impairment.
• Kidney - Use with caution in patients with severe renal impairment; no specific dose adjustment for mild to moderate impairment.
• Lung - Can cause interstitial lung disease/pneumonitis; monitor for new or worsening respiratory symptoms like cough or dyspnea.

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