PAZINIB 400 MG TAB 30'S

About

PAZINIB 400 MG TAB 30'S, containing Pazopanib, is a multi-targeted receptor tyrosine kinase inhibitor (TKI) used in the treatment of advanced cancers. It works by blocking several key signaling pathways involved in tumor growth, angiogenesis (formation of new blood vessels that feed tumors), and tumor cell survival. Specifically, Pazopanib inhibits vascular endothelial growth factor receptor (VEGFR)-1, -2, and -3, platelet-derived growth factor receptor (PDGFR)-α and -β, fibroblast growth factor receptor (FGFR)-1 and -3, c-Kit, and other tyrosine kinases. By targeting these multiple pathways, Pazopanib effectively slows down tumor progression and reduces tumor size.

This medication is primarily indicated for the treatment of advanced renal cell carcinoma (RCC) and advanced soft tissue sarcoma (STS) in patients who have received prior chemotherapy. Its oral administration offers convenience for patients, allowing for outpatient treatment. Due to its potent anti-angiogenic and anti-proliferative effects, Pazopanib has demonstrated significant improvements in progression-free survival in these challenging malignancies. Close monitoring for potential side effects, particularly hypertension and liver toxicity, is crucial to ensure patient safety and optimize therapeutic outcomes.

Uses

• Treatment of advanced renal cell carcinoma (RCC)
• Management of advanced soft tissue sarcoma (STS)
• Used in patients who have received prior chemotherapy
• Delaying disease progression in eligible patients

Directions For Use

Take orally once daily without food (at least 1 hour before or 2 hours after a meal), as directed by your oncologist.

Benefits

• Targeted therapy for specific advanced cancers
• Improves progression-free survival in RCC and STS
• Oral administration offers patient convenience
• Effective in metastatic settings, reducing tumor burden
• Blocks multiple pathways crucial for tumor growth
• Extends the period of disease control for patients

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Fatigue
• Hypertension (high blood pressure)
• Hair color changes
• Elevated liver enzymes
• Proteinuria (protein in urine)
• Hand-foot syndrome
• Headache
• Skin rash
• Arterial thrombotic events (rare)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to the potential for increased liver toxicity and gastrointestinal upset, which can exacerbate side effects.
• Pregnancy - Contraindicated during pregnancy due to its teratogenic potential. Women of childbearing potential must use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it is excreted in human milk and could cause serious adverse reactions in the infant.
• Liver - Contraindicated in severe hepatic impairment. Dose adjustment is required in moderate impairment, and liver function tests must be monitored closely and frequently.
• Kidney - Use with caution in patients with renal impairment. No specific dose adjustment guidelines for severe impairment, but monitor closely for adverse effects.
• Lung - Monitor for signs and symptoms of interstitial lung disease or pneumonitis. Discontinue treatment if suspected and manage appropriately.

Disclaimer

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