Abiratred 500mg Tablet

About

Abiratred 500mg Tablet contains an active ingredient that is a potent and selective inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase), an enzyme expressed in testicular, adrenal, and prostatic tumor tissues that is required for androgen biosynthesis. By inhibiting CYP17, Abiratred significantly reduces the production of androgens, including testosterone, in the testes, adrenal glands, and prostate tumor.

This reduction in androgen levels is critical because prostate cancer growth is often driven by androgens. It is used in combination with prednisone or prednisolone for the treatment of metastatic castration-resistant prostate cancer (mCRPC), offering a targeted approach to hormone-sensitive malignancies.

Uses

• Treatment of metastatic castration-resistant prostate cancer.
• Used in combination with corticosteroids.
• Management of high-risk metastatic hormone-sensitive prostate cancer.
• Reduces androgen production in prostate cancer patients.

Directions For Use

Take the tablets orally once daily on an empty stomach (at least two hours after food and one hour before food). Swallow whole with water.

Benefits

• Significantly prolongs overall survival in mCRPC.
• Delays disease progression in prostate cancer.
• Reduces prostate-specific antigen (PSA) levels.
• Offers a non-chemotherapeutic option for advanced prostate cancer.
• Improves quality of life for patients.
• Effective in both pre- and post-chemotherapy settings.

Side Effects

• Fatigue
• Joint swelling or pain
• Hot flashes
• Diarrhea
• High blood pressure
• Hypokalemia (low potassium)
• Fluid retention
• Urinary tract infection
• Elevated liver enzymes
• Cardiac disorders (e.g., arrhythmia)
• Adrenal insufficiency
• Muscle weakness

Safety Measures

• Alcohol - No specific interaction with alcohol, but excessive intake should be avoided due to potential liver strain.
• Pregnancy - Contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing potential should avoid contact.
• Breastfeeding - Not applicable, as it is used in men. However, if a woman were to be exposed, breastfeeding should be avoided.
• Liver - Use with caution in patients with moderate hepatic impairment; contraindicated in severe hepatic impairment.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe impairment.
• Lung - No specific contraindications related to lung conditions, but monitor for fluid retention that could impact respiratory function.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.