Abirated 500mg Tablet 20'S

About

Abirated 500mg Tablet contains Abiraterone, an androgen biosynthesis inhibitor that specifically targets cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is critically involved in the synthesis of androgens in the testes, adrenal glands, and prostate tumor tissue. By inhibiting CYP17, abiraterone significantly reduces the production of androgens, such as testosterone, which are known to fuel the growth of prostate cancer. This reduction in androgen levels helps to slow the progression of the disease. Abiraterone is typically used in combination with prednisone to manage mineralocorticoid excess side effects.

Uses

• Treatment of metastatic castration-resistant prostate cancer (mCRPC)
• Management of metastatic high-risk castration-sensitive prostate cancer (mCSPC)
• Prostate cancer progressing after androgen deprivation therapy
• Hormone-sensitive prostate cancer

Directions For Use

Take orally once daily on an empty stomach, at least one hour before or two hours after food. Always take in combination with prednisone as directed by your doctor.

Benefits

• Significantly prolongs overall survival in metastatic castration-resistant prostate cancer.
• Delays disease progression and reduces the risk of skeletal-related events.
• Effectively lowers prostate-specific antigen (PSA) levels.
• Offers a valuable treatment option in both pre- and post-chemotherapy settings.
• Convenient oral administration for long-term management.
• Improves quality of life for patients by controlling symptoms.

Side Effects

• Fatigue
• Joint swelling or discomfort (arthralgia)
• Hot flashes
• Diarrhea
• Hypertension (high blood pressure)
• Hypokalemia (low potassium levels)
• Fluid retention (edema)
• Liver enzyme elevation
• Urinary tract infection
• Peripheral edema
• Hypertriglyceridemia
• Adrenal insufficiency (if prednisone is discontinued abruptly)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption, as it may exacerbate liver enzyme elevations and potentially increase the risk of hepatotoxicity.
• Pregnancy - Contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing potential should avoid contact with crushed or broken tablets.
• Breastfeeding - Not applicable for male patients. For female caregivers, avoid contact with crushed or broken tablets and wash hands thoroughly after handling.
• Liver - Use with caution in patients with moderate hepatic impairment; contraindicated in severe hepatic impairment. Monitor liver function tests closely and regularly.
• Kidney - No dose adjustment is typically needed for mild to moderate renal impairment. Use with caution in severe renal impairment, with close monitoring.
• Lung - No specific lung-related precautions, but monitor for any new or worsening respiratory symptoms, though pulmonary toxicity is rare.

Disclaimer

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