Amitant Kit 125mg/80mg Capsule

About

This kit likely contains Aprepitant, a selective high-affinity antagonist of human substance P neurokinin 1 (NK1) receptors, specifically designed for the prevention of chemotherapy-induced nausea and vomiting (CINV). Aprepitant exerts its antiemetic effect by blocking the binding of substance P, a key neuropeptide, to the NK1 receptor located in the brainstem's chemoreceptor trigger zone. This action effectively inhibits both the acute and delayed phases of CINV, which are often debilitating side effects of highly and moderately emetogenic chemotherapy regimens. The typical 125mg/80mg dosage regimen involves a loading dose on day 1 before chemotherapy, followed by maintenance doses on days 2 and 3. This sequential dosing strategy significantly enhances its antiemetic efficacy, particularly when used in combination with other antiemetic agents such as 5-HT3 receptor antagonists and corticosteroids, providing comprehensive protection against CINV.

Uses

• Prevention of acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy.
• Prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy.
• Used in combination with a 5-HT3 antagonist and a corticosteroid.
• Prevention of postoperative nausea and vomiting (POVN) in some formulations.

Directions For Use

Take the capsules orally as directed by your doctor, typically starting one hour before chemotherapy on day 1, followed by daily doses on days 2 and 3. Swallow whole with water.

Benefits

• Highly effective in preventing both acute and delayed CINV.
• Significantly improves patient comfort during chemotherapy.
• Reduces the need for rescue antiemetics.
• Works synergistically with other antiemetic agents.
• Oral formulation offers convenience.
• Helps maintain nutritional intake during treatment.

Side Effects

• Fatigue
• Hiccups
• Constipation
• Diarrhea
• Headache
• Dizziness
• Loss of appetite
• Abdominal pain
• Dyspepsia
• Weakness
• Neutropenia
• Elevated liver enzymes

Safety Measures

• Alcohol - No specific contraindication, but alcohol can cause nausea and vomiting, potentially masking or worsening symptoms.
• Pregnancy - Use only if clearly needed and the potential benefit outweighs the potential risk to the fetus; consult a doctor.
• Breastfeeding - It is unknown if aprepitant is excreted in human milk; caution should be exercised when administered to a nursing mother.
• Liver - Use with caution in patients with severe hepatic impairment as aprepitant is extensively metabolized by the liver.
• Kidney - No dose adjustment is necessary for patients with renal impairment or end-stage renal disease requiring hemodialysis.
• Lung - Generally no specific precautions for lung conditions; however, monitor for any unusual respiratory symptoms.

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