ANGIPLAT 6.5 TAB

About

Isosorbide mononitrate is a long-acting nitrate primarily used for the prophylaxis of angina pectoris (chest pain) due to coronary artery disease. It works by releasing nitric oxide, which activates guanylate cyclase, leading to an increase in cyclic GMP in vascular smooth muscle. This results in relaxation of both arterial and venous smooth muscle. The predominant effect is venodilation, which reduces preload on the heart by decreasing venous return. Arterial dilation also occurs, reducing systemic vascular resistance and afterload. By reducing both preload and afterload, isosorbide mononitrate decreases myocardial oxygen demand, thereby preventing anginal attacks. It is not intended for the immediate relief of acute anginal attacks but rather for sustained prophylactic treatment to reduce the frequency and severity of angina.

Uses

• Prophylaxis of angina pectoris.
• Long-term management of coronary artery disease.
• To reduce the frequency and severity of anginal attacks.
• Adjunctive therapy in heart failure (off-label or specific guidelines).

Directions For Use

Take this medication orally, usually once or twice daily, as directed by your physician. Do not crush or chew extended-release tablets.

Benefits

• Effectively prevents anginal attacks.
• Reduces the frequency and severity of chest pain.
• Improves exercise tolerance in angina patients.
• Long-acting formulation for sustained relief.
• Reduces myocardial oxygen demand.
• Helps manage chronic stable angina.

Side Effects

• Headache (common, often resolves)
• Dizziness
• Lightheadedness
• Hypotension
• Flushing
• Nausea
• Vomiting
• Tachycardia (reflex)
• Weakness
• Syncope (fainting)
• Rash
• Orthostatic hypotension

Safety Measures

• Alcohol - Alcohol can significantly enhance the hypotensive effects of isosorbide mononitrate, leading to severe dizziness and fainting. Avoid alcohol.
• Pregnancy - Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Consult a doctor.
• Breastfeeding - It is unknown if isosorbide mononitrate passes into breast milk. Use with caution and consult a healthcare professional.
• Liver - Use with caution in patients with severe liver impairment; dosage adjustments may be necessary.
• Kidney - Use with caution in patients with severe renal impairment; dosage adjustments may be necessary.
• Lung - Generally safe for use in patients with lung conditions; no specific contraindications related to lung function.

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