Aprebion Kit Capsule

About

Aprebion Kit Capsule contains aprepitant, an antiemetic agent that selectively blocks the neurokinin-1 (NK1) receptor. This mechanism of action helps prevent both acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). By targeting the substance P/NK1 pathway in the central nervous system, aprepitant significantly reduces the incidence and severity of chemotherapy-induced nausea and vomiting (CINV), improving patient comfort and adherence to treatment regimens. It is typically administered as part of a multi-drug antiemetic regimen, often in combination with a corticosteroid and a 5-HT3 receptor antagonist, to provide comprehensive CINV prophylaxis.

Uses

• Prevention of acute chemotherapy-induced nausea and vomiting.
• Prevention of delayed chemotherapy-induced nausea and vomiting.
• Used with highly emetogenic chemotherapy regimens.
• Used with moderately emetogenic chemotherapy regimens.

Directions For Use

Take as directed by your physician, usually starting before chemotherapy.
Swallow the capsules whole with water, with or without food.

Benefits

• Highly effective in preventing CINV.
• Reduces both acute and delayed nausea.
• Improves patient quality of life during chemotherapy.
• Enhances adherence to chemotherapy schedules.
• Works synergistically with other antiemetics.
• Provides sustained antiemetic protection.

Side Effects

• Fatigue
• Hiccups
• Constipation
• Diarrhea
• Headache
• Dizziness
• Loss of appetite
• Dyspepsia
• Abdominal pain
• Weakness
• Neutropenia
• Increased liver enzymes

Safety Measures

• Alcohol - Alcohol consumption should be avoided or minimized as it may exacerbate side effects like dizziness or fatigue.
• Pregnancy - Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Consult a doctor.
• Breastfeeding - It is unknown if aprepitant is excreted in human milk. A decision should be made whether to discontinue nursing or the drug.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustments may be necessary.
• Kidney - No dose adjustment is generally required for patients with renal impairment.
• Lung - No specific precautions are typically needed for patients with pre-existing lung conditions.

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