Aprelieva 125mg Capsule

About

Aprelieva 125mg Capsule is an oral antiemetic medication, likely a neurokinin-1 (NK1) receptor antagonist, primarily used for the prevention of chemotherapy-induced nausea and vomiting (CINV). It functions by selectively blocking the NK1 receptors in the central nervous system, thereby inhibiting the action of substance P, a key neurotransmitter involved in the emetic reflex. This mechanism allows Aprelieva to effectively prevent both the acute and delayed phases of nausea and vomiting associated with highly emetogenic chemotherapy regimens. The oral capsule form provides a convenient option for patients to continue antiemetic therapy at home.

The capsule is absorbed orally and typically administered as part of a multi-day regimen, often in conjunction with other antiemetics like corticosteroids and 5-HT3 receptor antagonists, to ensure comprehensive control of CINV. Its prolonged action helps to manage delayed CINV, which can persist for several days after chemotherapy. Adherence to the prescribed dosing schedule is crucial for optimal efficacy. Patients should be monitored for potential drug interactions, especially with medications metabolized by CYP3A4.

Uses

• Prevention of acute chemotherapy-induced nausea and vomiting (CINV).
• Prevention of delayed CINV.
• Used in combination with other antiemetics for highly emetogenic chemotherapy.
• Prophylaxis against post-operative nausea and vomiting (PONV) in some cases.

Directions For Use

Take orally with water, as directed by your doctor, usually before and after chemotherapy sessions.

Benefits

• Highly effective in preventing CINV.
• Controls both acute and delayed nausea and vomiting.
• Significantly improves patient comfort during chemotherapy.
• Reduces the need for rescue antiemetics.
• Enhances adherence to chemotherapy regimens.
• Convenient oral formulation for home use.

Side Effects

• Fatigue
• Headache
• Dizziness
• Hiccups
• Constipation
• Diarrhea
• Nausea (despite medication)
• Abdominal pain
• Dyspepsia
• Anorexia
• Weakness
• Elevated liver enzymes

Safety Measures

• Alcohol - No specific contraindication, but alcohol can exacerbate nausea and vomiting, so avoidance is generally advised.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks; consult a doctor.
• Breastfeeding - Unknown if excreted in breast milk; use with caution or avoid. Consult a doctor.
• Liver - Use with caution in severe liver impairment; monitor liver function.
• Kidney - No dosage adjustment typically required for kidney impairment.
• Lung - Generally safe for use in patients with lung conditions.

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