Aromasin 25mg Tablet

About

Exemestane, known commercially as Aromasin, is a unique steroidal aromatase inactivator that functions through an irreversible binding mechanism. Unlike non-steroidal inhibitors, exemestane acts as a "suicide inhibitor," forming a permanent covalent bond with the active site of the aromatase enzyme. This irreversible inactivation prevents the enzyme from converting androgens into estrogens, leading to a profound and sustained reduction in estrogen levels in postmenopausal women. This sustained estrogen deprivation is crucial for inhibiting the growth of hormone-receptor-positive breast cancer cells, which rely on estrogen for proliferation. Exemestane is primarily indicated for the adjuvant treatment of early breast cancer in postmenopausal women who have completed initial tamoxifen therapy, and for the treatment of advanced breast cancer, providing a robust and long-lasting endocrine blockade.

Uses

• Adjuvant treatment of early breast cancer
• Treatment of advanced breast cancer
• Hormone-receptor-positive breast cancer
• After tamoxifen therapy

Directions For Use

Take one tablet orally once daily after a meal, as prescribed by your oncologist. Swallow the tablet whole with water.

Benefits

• Irreversible aromatase inactivation
• Significantly reduces estrogen levels
• Effective in hormone-sensitive breast cancer
• Improves disease-free survival
• Oral administration
• Can be used after tamoxifen failure

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Nausea
• Headache
• Insomnia
• Increased sweating
• Bone thinning (osteoporosis)
• Vaginal dryness
• Hair thinning
• Depression
• Peripheral edema

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but it's generally advisable to limit alcohol intake during cancer treatment.
• Pregnancy - Contraindicated in premenopausal women and during pregnancy due to potential harm to the fetus. Effective contraception is required if there is any potential for pregnancy.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if exemestane is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with moderate to severe liver impairment. Liver function should be monitored regularly.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment.
• Lung - No specific contraindications related to lung conditions. Monitor for any new or worsening respiratory symptoms.

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