Asparawem 5000IU Injection

About

Asparawem 5000IU Injection contains Asparaginase, an enzyme that catalyzes the hydrolysis of asparagine into aspartic acid and ammonia. Certain cancer cells, particularly those found in acute lymphoblastic leukemia (ALL), are unable to synthesize asparagine and are therefore dependent on external sources of this amino acid for their survival and proliferation. By depleting circulating asparagine, Asparawem selectively starves these cancer cells, leading to their death.

This medication is a critical component of multi-agent chemotherapy regimens for acute lymphoblastic leukemia (ALL) and some lymphomas, playing a vital role in achieving remission and improving long-term outcomes for patients.

Uses

• Acute lymphoblastic leukemia (ALL)
• Some non-Hodgkin lymphomas
• Acute myeloid leukemia (AML) (less common)
• Induction therapy for ALL

Directions For Use

Administered intramuscularly or intravenously by a healthcare professional, according to specific treatment protocols and patient needs.

Benefits

• Essential for ALL treatment protocols
• Achieves high response rates in ALL
• Part of curative chemotherapy regimens
• Targets specific metabolic pathway of cancer cells
• Effective in both pediatric and adult ALL
• Well-established chemotherapy agent

Side Effects

• Hypersensitivity reactions (anaphylaxis)
• Pancreatitis
• Hyperglycemia
• Coagulopathy (thrombosis or hemorrhage)
• Liver dysfunction
• Nausea
• Vomiting
• Fever
• Chills
• Fatigue
• Headache
• CNS toxicity

Safety Measures

• Alcohol - Avoid or limit alcohol, as it may exacerbate liver toxicity or increase the risk of pancreatitis.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Use effective contraception.
• Breastfeeding - Not recommended during breastfeeding due to the potential for serious adverse reactions in infants.
• Liver - Use with extreme caution; can cause severe hepatotoxicity. Monitor liver function closely.
• Kidney - Use with caution; monitor renal function. Dose adjustment may be needed in severe impairment.
• Lung - Monitor for signs of pulmonary toxicity, including allergic reactions or acute respiratory distress.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.