CELGINASE 5000 IU INJ. VIAL.

About

Asparaginase is an enzyme-based antineoplastic agent critical in the treatment of acute lymphoblastic leukemia (ALL). Its unique mechanism of action involves depleting asparagine, a non-essential amino acid that is, paradoxically, essential for the survival and proliferation of certain leukemic cells. These specific leukemic cells lack the enzyme asparagine synthetase, rendering them unable to synthesize their own asparagine and thus dependent on exogenous sources. Normal healthy cells, however, possess asparagine synthetase and are largely unaffected by asparagine depletion. By hydrolyzing asparagine into aspartic acid and ammonia, asparaginase effectively starves these leukemic cells, inhibiting their protein synthesis and ultimately leading to cell death. It is a vital component of multi-agent chemotherapy regimens for both pediatric and adult ALL, administered intravenously or intramuscularly.

Uses

• Acute Lymphoblastic Leukemia (ALL)
• Lymphoma (certain types, off-label)
• Induction therapy for ALL
• Relapsed/refractory ALL

Directions For Use

Administer intravenously or intramuscularly as directed by a physician. Do not shake the vial.

Benefits

• Essential for ALL treatment
• Induces remission in ALL
• Targets asparagine-dependent cells
• Part of curative regimens
• Effective in both pediatric and adult ALL
• Can be used in combination therapy

Side Effects

• Hypersensitivity reactions (anaphylaxis, rash, urticaria)
• Pancreatitis
• Coagulopathy (thrombosis, hemorrhage)
• Hyperglycemia
• Elevated liver enzymes
• Nausea
• Vomiting
• Fever
• Headache
• CNS toxicity (lethargy, confusion)
• Renal dysfunction
• Hypoalbuminemia

Safety Measures

• Alcohol - No specific interaction, but avoid excessive alcohol due to potential for exacerbating pancreatitis or liver stress.
• Pregnancy - Contraindicated due to potential for fetal harm; effective contraception is essential.
• Breastfeeding - Not recommended; discontinue breastfeeding during treatment.
• Liver - Use with extreme caution in patients with hepatic impairment; monitor liver function closely due to risk of hepatotoxicity.
• Kidney - Use with caution in patients with renal impairment; monitor renal function closely.
• Lung - Monitor for respiratory symptoms, as hypersensitivity reactions can include bronchospasm and dyspnea.

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