About
Atorvastatin and Fenofibrate, often combined as ATOCOR F, is a medication used to treat mixed dyslipidemia, a condition characterized by elevated levels of both triglycerides and low-density lipoprotein cholesterol (LDL-C), and often low high-density lipoprotein cholesterol (HDL-C). Atorvastatin, a statin, works by inhibiting HMG-CoA reductase, reducing cholesterol synthesis in the liver and lowering LDL-C. Fenofibrate, a fibric acid derivative, primarily activates peroxisome proliferator-activated receptor alpha (PPARα), which leads to a reduction in triglyceride levels and an increase in HDL-C.
This combination therapy is particularly beneficial for patients who require comprehensive lipid management beyond what a single agent can provide. It addresses multiple lipid abnormalities, thereby reducing the overall risk of cardiovascular disease. The synergistic action of these two drugs helps achieve more aggressive lipid targets. Regular monitoring of lipid profiles, liver function, and muscle-related symptoms is crucial during treatment to ensure efficacy and safety, especially given the potential for increased side effects when statins and fibrates are co-administered.
Uses
- Treats mixed dyslipidemia.
- Lowers high triglycerides.
- Reduces high LDL-C.
- Increases low HDL-C.
Directions For Use
Take one tablet orally once daily, with or without food, as directed by your physician. Do not crush or chew the tablet.
Benefits
- Comprehensive lipid profile improvement.
- Significantly lowers both LDL-C and triglycerides.
- Increases beneficial HDL-C.
- Reduces overall cardiovascular risk.
- Offers synergistic lipid-lowering effects.
- Convenient single-pill combination.
Side Effects
- Muscle pain (myalgia).
- Elevated liver enzymes.
- Gastrointestinal upset.
- Headache.
- Nausea.
- Abdominal pain.
- Pancreatitis (rare).
- Gallstones (rare).
- Kidney dysfunction.
- Fatigue.
- Dizziness.
- Skin rash.
Safety Measures
- Alcohol - Limit alcohol intake due to increased risk of liver problems; consult a doctor.
- Pregnancy - Contraindicated; can cause fetal harm. Use effective contraception.
- Breastfeeding - Contraindicated; unknown if excreted in human milk and potential for serious adverse effects.
- Liver - Contraindicated in active liver disease; monitor liver function tests regularly.
- Kidney - Use with caution in moderate to severe impairment; dose adjustment may be necessary.
- Lung - Generally safe; no specific contraindications for lung conditions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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