Avastimab 400mg Injection

About

Avastimab 400mg Injection is a biosimilar to Bevacizumab, a monoclonal antibody used in the treatment of various cancers. It functions by targeting and inhibiting vascular endothelial growth factor (VEGF), a crucial protein involved in angiogenesis, the process by which new blood vessels are formed. Tumors rely on these new blood vessels for growth and metastasis. By blocking VEGF, Avastimab effectively cuts off the tumor's blood supply, thereby impeding its proliferation and spread. This medication is frequently administered in conjunction with chemotherapy for advanced or metastatic cancers, including colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, and ovarian cancer. Its anti-angiogenic mechanism makes it a vital component of comprehensive cancer therapy, aiming to enhance patient outcomes and extend survival by disrupting the tumor's ability to grow and invade.

Uses

• Treatment of metastatic colorectal cancer.
• Management of non-small cell lung cancer.
• Therapy for glioblastoma.
• Treatment of metastatic renal cell carcinoma.

Directions For Use

Administer intravenously under the supervision of a qualified healthcare professional. Dosage and frequency are determined by the specific cancer type and patient's body weight.

Benefits

• Inhibits tumor growth and spread.
• Reduces blood supply to tumors.
• Extends progression-free survival in various cancers.
• Often used effectively in combination with chemotherapy.
• Targets a key pathway in cancer development (angiogenesis).
• Improves overall survival in specific indications.

Side Effects

• Hypertension (high blood pressure)
• Proteinuria (protein in urine)
• Bleeding events
• Thromboembolic events (blood clots)
• Gastrointestinal perforation
• Wound healing complications
• Fatigue
• Headache
• Diarrhea
• Nausea
• Neutropenia
• Infusion-related reactions

Safety Measures

• Alcohol - No specific contraindication, but general health advice to limit alcohol during cancer treatment applies.
• Pregnancy - Contraindicated during pregnancy due to potential for severe fetal harm; effective contraception is mandatory during and for a period after treatment.
• Breastfeeding - Not recommended during breastfeeding due to the potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with liver impairment; monitor liver function, though not primarily metabolized by the liver.
• Kidney - Use with caution in patients with kidney impairment; monitor renal function, especially for proteinuria.
• Lung - Use with caution in patients with a history of hemoptysis or lung hemorrhage, as it can increase bleeding risk.

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