Bevacirel 400mg Injection

About

Bevacizumab is a recombinant humanized monoclonal antibody that specifically targets vascular endothelial growth factor (VEGF). VEGF is a crucial protein that plays a pivotal role in angiogenesis, the process by which new blood vessels are formed, which is essential for tumor growth, survival, and metastasis. By binding to VEGF, bevacizumab effectively prevents its interaction with VEGF receptors on endothelial cells. This action inhibits the proliferation and migration of endothelial cells, thereby disrupting the formation of new blood vessels that supply oxygen and nutrients to cancerous tumors. This targeted mechanism makes bevacizumab a potent antineoplastic agent, widely utilized in the treatment of various solid tumors to slow disease progression and improve patient outcomes.

Uses

• Metastatic colorectal cancer
• Non-small cell lung cancer
• Glioblastoma
• Metastatic renal cell carcinoma

Directions For Use

Administer intravenously under the supervision of a healthcare professional. Dosage and infusion rate are determined by the patient's weight and specific cancer type.

Benefits

• Inhibits tumor angiogenesis
• Slows tumor growth and progression
• Improves progression-free survival
• Can be used in combination therapies
• Targets a critical pathway in cancer
• Reduces tumor vascularity

Side Effects

• Hypertension
• Proteinuria
• Thromboembolic events
• Hemorrhage
• Gastrointestinal perforation
• Wound healing complications
• Fatigue
• Headache
• Diarrhea
• Nausea
• Neutropenia
• Taste alteration

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate fatigue or other systemic side effects.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm; use effective contraception.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant.
• Liver - Use with caution in patients with pre-existing liver conditions; monitor liver function.
• Kidney - Monitor for proteinuria and renal function; dose adjustment may be needed in severe impairment.
• Lung - Use with caution in patients with a history of pulmonary hemorrhage or other lung conditions.

Disclaimer

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