Biobraxane 100mg Injection

About

Paclitaxel protein-bound, often referred to as nab-paclitaxel, is an albumin-bound nanoparticle formulation of paclitaxel, an antineoplastic agent. This formulation allows for higher doses of paclitaxel to be delivered with reduced solvent-related toxicities, such as hypersensitivity reactions, compared to conventional paclitaxel. It exerts its cytotoxic effects by promoting microtubule assembly and inhibiting depolymerization, thereby stabilizing microtubules and disrupting the dynamic equilibrium required for cell division. This leads to cell cycle arrest and apoptosis in cancer cells. Nab-paclitaxel is administered intravenously and is indicated for the treatment of metastatic breast cancer, non-small cell lung cancer, and pancreatic adenocarcinoma. Its unique formulation facilitates enhanced tumor penetration and accumulation, contributing to its efficacy. Close monitoring for myelosuppression and peripheral neuropathy is essential during treatment to manage potential dose-limiting toxicities effectively.

Uses

• Metastatic breast cancer
• Non-small cell lung cancer
• Pancreatic adenocarcinoma
• Advanced gastric cancer (off-label in some regions)

Directions For Use

Administered intravenously by a healthcare professional. Dosage and infusion rate are determined by the specific cancer type and patient tolerance.

Benefits

• Effective against various solid tumors.
• Reduced risk of hypersensitivity reactions compared to conventional paclitaxel.
• Does not require pre-medication with corticosteroids.
• Improved tumor penetration due to nanoparticle formulation.
• Can be used in patients intolerant to solvent-based paclitaxel.
• Offers a valuable option in advanced cancer settings.

Side Effects

• Peripheral neuropathy
• Myelosuppression (neutropenia, anemia)
• Fatigue
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea
• Muscle and joint pain
• Edema (swelling)
• Hypersensitivity reactions (less common)
• Infection
• Liver enzyme elevation

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate liver toxicity and gastrointestinal side effects.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm; use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk.
• Liver - Use with caution and dose adjustment in patients with moderate to severe liver impairment.
• Kidney - Generally safe in kidney impairment, but monitor for potential accumulation of metabolites.
• Lung - Use with caution in patients with pre-existing lung conditions; monitor for interstitial lung disease.

Disclaimer

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