About
Amlodipine is a widely prescribed dihydropyridine calcium channel blocker, primarily indicated for the management of essential hypertension and various forms of angina pectoris, including chronic stable angina and vasospastic angina (Prinzmetal's angina). Its therapeutic action involves relaxing the smooth muscles within the arterial walls, leading to peripheral vasodilation. This reduction in systemic vascular resistance effectively lowers blood pressure and decreases the workload on the heart, thereby improving myocardial oxygen supply and alleviating anginal symptoms. Amlodipine's pharmacokinetic profile is characterized by a gradual onset and prolonged duration of action, allowing for convenient once-daily administration. This ensures consistent blood pressure control throughout a 24-hour period, contributing to better patient adherence and sustained therapeutic benefits. It can be utilized as a monotherapy or in combination with other antihypertensive agents to achieve optimal blood pressure targets, making it a versatile option in cardiovascular management.
Uses
- Management of essential hypertension.
- Treatment of chronic stable angina.
- Management of vasospastic angina (Prinzmetal's angina).
- Adjunctive therapy for heart failure with reduced ejection fraction (in specific cases).
Directions For Use
Take orally once daily, with or without food, as directed by your physician. Do not crush or chew the tablet.
Benefits
- Effective in lowering high blood pressure.
- Reduces frequency and severity of angina attacks.
- Provides 24-hour blood pressure control.
- Can be used in patients with diabetes or kidney disease.
- Well-tolerated in most patients.
- Available in various strengths for flexible dosing.
Side Effects
- Peripheral edema (swelling of ankles/feet)
- Headache
- Dizziness
- Flushing
- Fatigue
- Palpitations
- Nausea
- Abdominal pain
- Somnolence
- Muscle cramps
- Gingival hyperplasia
- Rash
Safety Measures
- Alcohol - Alcohol may enhance the blood pressure-lowering effect of amlodipine, potentially leading to dizziness or fainting. Use with caution.
- Pregnancy - Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
- Breastfeeding - Amlodipine is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
- Liver - Use with caution in patients with impaired liver function, as amlodipine metabolism may be reduced, requiring dose adjustment.
- Kidney - No dosage adjustment is typically required for patients with renal impairment, but monitor closely in severe cases.
- Lung - Generally safe for use in patients with lung conditions, as it does not directly affect respiratory function.
Disclaimer
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