About
Amlodipine is a widely prescribed dihydropyridine calcium channel blocker, primarily indicated for the management of essential hypertension and various forms of angina pectoris, including chronic stable angina and vasospastic angina (Prinzmetal's angina). Its therapeutic action involves relaxing the smooth muscles within the arterial walls, leading to peripheral vasodilation. This reduction in systemic vascular resistance effectively lowers blood pressure and decreases the workload on the heart, thereby improving myocardial oxygen supply and alleviating anginal symptoms. Amlodipine's pharmacokinetic profile is characterized by a gradual onset and prolonged duration of action, allowing for convenient once-daily administration. This ensures consistent blood pressure control throughout a 24-hour period, contributing to better patient adherence and sustained therapeutic benefits. It can be utilized as a monotherapy or in combination with other antihypertensive agents to achieve optimal blood pressure targets, making it a versatile option in cardiovascular management.
Uses
- Treatment of high blood pressure.
- Management of chronic stable angina.
- Relief of vasospastic angina.
- As part of combination therapy for hypertension.
Directions For Use
Take one tablet orally once daily, at the same time each day, with or without food. Swallow the tablet whole.
Benefits
- Provides sustained blood pressure reduction.
- Effectively reduces the frequency of angina attacks.
- Offers 24-hour control with once-daily dosing.
- Generally well-tolerated by patients.
- Can be used in various patient populations.
- Helps prevent cardiovascular complications.
Side Effects
- Swelling of the ankles or feet
- Headache
- Dizziness
- Flushing
- Fatigue
- Palpitations
- Nausea
- Abdominal pain
- Somnolence
- Muscle cramps
- Gingival hyperplasia
- Rash
Safety Measures
- Alcohol - Alcohol may potentiate the hypotensive effects of amlodipine, increasing the risk of dizziness or lightheadedness. Consume alcohol cautiously.
- Pregnancy - Use during pregnancy should be considered only if the potential benefits outweigh the potential risks to the fetus. Consult your doctor.
- Breastfeeding - Amlodipine is known to be excreted in breast milk. A decision on whether to discontinue nursing or the drug should be made with a healthcare professional.
- Liver - Patients with impaired liver function may require a lower starting dose and careful monitoring due to reduced drug clearance.
- Kidney - No dose adjustment is typically needed for patients with renal impairment, but caution is advised in severe cases.
- Lung - Amlodipine is generally safe for patients with pulmonary conditions, as it does not directly impact respiratory function.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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