CISBLOK 10MG INJ 5ML

About

CISBLOK 10MG INJ 5ML contains Cisatracurium, a non-depolarizing neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the intensive care unit (ICU). It acts by competing with acetylcholine for receptor sites on the motor end-plate, thereby preventing depolarization and muscle contraction. Cisatracurium is particularly valued for its unique metabolism, undergoing Hofmann elimination (pH and temperature-dependent degradation) and ester hydrolysis, which makes its elimination largely independent of renal and hepatic function. This pharmacokinetic profile makes it a preferred choice for patients with significant kidney or liver impairment, offering a predictable duration of action and minimal accumulation.

Uses

• Facilitation of tracheal intubation
• Skeletal muscle relaxation during surgery
• Muscle relaxation for mechanical ventilation in ICU
• Adjunct to general anesthesia

Directions For Use

Administer intravenously by a trained healthcare professional. Dosage is individualized based on patient weight, renal/hepatic function, and desired duration of blockade.

Benefits

• Predictable onset and duration of action
• Minimal cardiovascular effects
• Undergoes Hofmann elimination, independent of organ function
• Suitable for patients with renal or hepatic impairment
• Low potential for histamine release
• Facilitates smooth surgical procedures and ventilation

Side Effects

• Bradycardia
• Hypotension
• Flushing
• Bronchospasm (rare)
• Rash
• Pruritus
• Muscle weakness (residual)
• Prolonged neuromuscular blockade
• Anaphylaxis (rare)
• Myopathy (with prolonged ICU use)
• Tachycardia (rare)
• Hypertension (rare)

Safety Measures

• Alcohol - Alcohol consumption is not directly relevant to the acute administration of Cisblok in a clinical setting, but patients should avoid alcohol before surgery as it can interact with anesthetics.
• Pregnancy - Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Consult a specialist.
• Breastfeeding - Exercise caution when administering to breastfeeding mothers. It is generally considered safe due to rapid metabolism, but consult a healthcare professional.
• Liver - Cisblok is largely metabolized by Hofmann elimination, making it a preferred choice for patients with liver conditions as its elimination is minimally affected.
• Kidney - Cisblok is largely metabolized by Hofmann elimination, making it a preferred choice for patients with kidney conditions as its elimination is minimally affected.
• Lung - Use with caution in patients with pre-existing pulmonary disease or asthma due to the potential for bronchospasm, although histamine release is minimal with Cisatracurium.

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