Cislee 10mg Injection

About

Cislee 10mg Injection contains Cisplatin, a potent platinum-based antineoplastic agent widely used in chemotherapy. It exerts its cytotoxic effects by forming DNA adducts, leading to inter- and intra-strand cross-links, which ultimately inhibit DNA synthesis and repair, triggering apoptosis in rapidly dividing cancer cells. This mechanism makes it effective against a broad spectrum of solid tumors. Administered intravenously, its use requires careful clinical supervision due to its narrow therapeutic index and significant toxicity profile.

The drug is a cornerstone in various combination chemotherapy regimens, aiming to maximize therapeutic efficacy while managing adverse effects. Its pharmacokinetics involve rapid distribution and extensive binding to plasma proteins, with excretion primarily via the kidneys. Due to its nephrotoxic potential, adequate hydration and monitoring of renal function are critical during treatment to mitigate kidney damage.

Uses

• Treatment of advanced ovarian cancer.
• Management of metastatic testicular cancer.
• Therapy for advanced bladder cancer.
• Used in head and neck squamous cell carcinoma.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are determined by the patient's condition and cancer type.

Benefits

• Highly effective against a wide range of solid tumors.
• Induces significant tumor regression in responsive cancers.
• Often used as a foundational agent in combination therapies.
• Can improve overall survival rates in specific malignancies.
• Well-established and extensively studied in oncology.
• Available in different strengths for precise dosing.

Side Effects

• Severe nausea and vomiting
• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss, tinnitus)
• Peripheral neuropathy
• Myelosuppression (low blood counts)
• Electrolyte disturbances (e.g., hypomagnesemia)
• Anaphylactic-like reactions
• Alopecia (hair loss)
• Fatigue and weakness
• Stomatitis (mouth sores)
• Diarrhea or constipation
• Elevated liver enzymes

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased gastrointestinal upset and liver strain, which can exacerbate cisplatin's side effects.
• Pregnancy - Contraindicated in pregnancy due to severe teratogenic effects and fetal harm. Effective contraception is essential during treatment.
• Breastfeeding - Not recommended during breastfeeding as cisplatin can pass into breast milk and harm the infant. Discontinue breastfeeding.
• Liver - Use with caution in patients with pre-existing liver conditions; liver function should be closely monitored due to potential hepatotoxicity.
• Kidney - Contraindicated or used with extreme caution in severe renal impairment due to significant nephrotoxicity. Hydration and renal function monitoring are crucial.
• Lung - Generally safe for use in patients with lung conditions, but monitor for any signs of pulmonary toxicity, though rare.

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