Cismax 50mg Injection

About

Cismax 50mg Injection contains Cisplatin, a platinum-based alkylating agent widely utilized in chemotherapy for various solid tumors. Its primary mechanism of action involves binding to DNA and forming intra- and inter-strand cross-links, which distorts the DNA helix and inhibits DNA replication and transcription. This ultimately leads to cell cycle arrest and apoptosis in rapidly proliferating cancer cells. Cisplatin is a non-cell cycle specific agent, meaning it can exert its cytotoxic effects on cancer cells regardless of their phase in the cell cycle.

Given its potent antineoplastic activity, Cisplatin is a foundational drug in many combination chemotherapy regimens, particularly for aggressive cancers. However, its use is associated with significant toxicities, including severe nephrotoxicity, ototoxicity, and emetogenicity. Therefore, meticulous patient management, including aggressive pre- and post-hydration, and prophylactic antiemetic therapy, is crucial during its intravenous administration in a hospital setting. Regular monitoring of renal function, electrolytes, and audiometry is essential to manage and mitigate these adverse effects.

Uses

• Testicular cancer
• Ovarian cancer
• Bladder cancer
• Head and neck cancer

Directions For Use

This medicine is administered intravenously by a qualified healthcare professional.

Pre-hydration and antiemetic medication are typically given before administration.

Benefits

• Highly effective in treating several solid tumors
• Curative potential in germ cell tumors
• Often used as a cornerstone in combination regimens
• Can achieve significant tumor response
• Established efficacy in various cancer types
• Contributes to improved survival outcomes

Side Effects

• Severe nausea and vomiting
• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss, tinnitus)
• Myelosuppression (low blood counts)
• Peripheral neuropathy (nerve damage)
• Electrolyte disturbances (hypomagnesemia, hypokalemia)
• Hypersensitivity reactions
• Alopecia (hair loss)
• Fatigue and weakness
• Anorexia (loss of appetite)
• Stomatitis (mouth sores)
• Hepatotoxicity (liver damage)

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment with Cismax 50mg Injection as it may exacerbate side effects, particularly nausea and liver toxicity.
• Pregnancy - Cismax 50mg Injection is contraindicated in pregnancy due to its severe teratogenic and embryotoxic effects. Effective contraception is mandatory for both male and female patients during and for a period after treatment.
• Breastfeeding - Breastfeeding is contraindicated during treatment with Cismax 50mg Injection due to the potential for serious adverse reactions in the breastfed infant.
• Liver - Use with caution in patients with hepatic impairment. Liver function should be monitored, and dose adjustments may be considered.
• Kidney - Cismax 50mg Injection is highly nephrotoxic. It is contraindicated in severe renal impairment and requires careful monitoring of kidney function with extensive hydration in all patients.
• Lung - Rare cases of pulmonary fibrosis have been reported. Monitor for new or worsening respiratory symptoms, especially with prolonged use.

Disclaimer

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