CLOPIVAS AP 75 15'S

About

Clopivas AP 75 is a combination antiplatelet medication containing Clopidogrel 75 mg and Aspirin 75 mg. Clopidogrel is a P2Y12 platelet inhibitor that prevents platelets from clumping together to form harmful clots. Aspirin, a non-steroidal anti-inflammatory drug (NSAID) and antiplatelet agent, inhibits cyclooxygenase, thereby reducing the production of thromboxane A2, another potent inducer of platelet aggregation. The dual antiplatelet therapy (DAPT) provided by this combination offers enhanced protection against thrombotic events.

This medication is primarily indicated for the prevention of atherothrombotic events in patients with acute coronary syndrome (ACS), including unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). It is also used for secondary prevention in patients with a history of myocardial infarction, ischemic stroke, or established peripheral arterial disease. The combination is crucial in patients undergoing percutaneous coronary intervention (PCI) with stent placement to prevent stent thrombosis and subsequent cardiovascular events.

Uses

• Prevents atherothrombotic events in acute coronary syndrome.
• Reduces risk of stroke, heart attack, and peripheral arterial disease.
• Prevents stent thrombosis after PCI.
• Used for secondary prevention of cardiovascular events.

Directions For Use

Take this medication orally, once daily, with or without food, as directed by your physician.

Benefits

• Provides powerful dual antiplatelet action.
• Significantly reduces risk of heart attack and stroke.
• Prevents blood clot formation in arteries.
• Crucial for post-stent placement care.
• Improves outcomes in acute coronary syndrome.
• Reduces risk of recurrent cardiovascular events.

Side Effects

• Increased bleeding risk (e.g., gastrointestinal, intracranial)
• Dyspepsia (indigestion)
• Abdominal pain
• Nausea
• Diarrhea
• Skin rash
• Bruising
• Epistaxis (nosebleeds)
• Purpura
• Headache
• Dizziness
• Tinnitus (ringing in ears)

Safety Measures

• Alcohol - Concurrent use of alcohol significantly increases the risk of gastrointestinal bleeding. It is strongly advised to avoid or limit alcohol consumption.
• Pregnancy - Not recommended during pregnancy, especially in the third trimester due to the aspirin component which can cause fetal harm and complications during delivery.
• Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk and pose risks to the infant.
• Liver - Use with caution in patients with hepatic impairment due to increased risk of bleeding. Regular monitoring may be required.
• Kidney - Use with caution in patients with renal impairment. Regular monitoring of kidney function is recommended, especially with the aspirin component.
• Lung - Caution is advised in patients with asthma or aspirin-induced respiratory disease due to the aspirin component, which can trigger bronchospasm.

Disclaimer

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