RAZEL A 75MG 10

About

This medication combines Rosuvastatin, an HMG-CoA reductase inhibitor (statin), with Aspirin (acetylsalicylic acid), an antiplatelet agent. Rosuvastatin works by reducing cholesterol synthesis in the liver, thereby lowering LDL-C, total cholesterol, and triglycerides, and increasing HDL-C. This action is crucial for preventing and managing atherosclerosis. Aspirin, at a low dose of 75mg, inhibits platelet aggregation by irreversibly acetylating cyclooxygenase-1 (COX-1), preventing the formation of thromboxane A2. This antiplatelet effect reduces the risk of blood clot formation, which is vital in preventing cardiovascular events like heart attacks and strokes. The combination is particularly beneficial for patients at high risk of recurrent cardiovascular events who require both lipid-lowering and antiplatelet therapy.

Uses

• Secondary prevention of cardiovascular events (e.g., heart attack, stroke).
• Management of dyslipidemia in high-risk patients.
• Prevention of thrombotic events in patients with established atherosclerotic disease.
• Reduction of overall cardiovascular mortality and morbidity.

Directions For Use

Take orally once daily, preferably at the same time each day, with or without food, as directed by your doctor. Do not crush or chew.

Benefits

• Effectively lowers "bad" cholesterol (LDL-C).
• Reduces the risk of blood clot formation.
• Significantly lowers the risk of heart attack and stroke.
• Stabilizes atherosclerotic plaques.
• Provides dual protection against cardiovascular disease.
• Convenient single-pill combination therapy.

Side Effects

• Myalgia (muscle pain)
• Headache
• Nausea, indigestion, heartburn
• Diarrhea or constipation
• Increased bleeding risk (due to aspirin)
• Abdominal pain
• Elevated liver enzymes
• Rhabdomyolysis (rare, statin component)
• Gastric ulcers or irritation (aspirin component)
• Tinnitus (ringing in ears, with higher aspirin doses)
• Allergic reactions (rash, angioedema)
• New-onset diabetes mellitus (small risk, statin component)

Safety Measures

• Alcohol - Excessive alcohol consumption can increase the risk of liver damage (statin) and gastrointestinal bleeding (aspirin). It is advisable to limit or avoid alcohol intake.
• Pregnancy - This combination is contraindicated in pregnancy due to the potential for fetal harm from both rosuvastatin and aspirin, especially in the third trimester.
• Breastfeeding - Both rosuvastatin and aspirin are excreted in breast milk. This combination is contraindicated during breastfeeding due to potential adverse effects on the infant.
• Liver - Rosuvastatin is contraindicated in active liver disease. Aspirin should be used with caution in severe liver impairment. Liver function tests should be monitored regularly.
• Kidney - Use with caution in patients with renal impairment. Dosage adjustments for rosuvastatin may be necessary. Aspirin should be used cautiously in severe renal dysfunction.
• Lung - Aspirin can exacerbate asthma in some sensitive individuals (aspirin-exacerbated respiratory disease). Rosuvastatin does not directly affect lung function, but caution is advised for the aspirin component.

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