About
Fenofibrate is a fibric acid derivative that acts as a peroxisome proliferator-activated receptor alpha (PPARα) agonist. Activation of PPARα leads to increased lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing the production of apolipoprotein C-III, an inhibitor of lipoprotein lipase. This results in a significant reduction in plasma triglycerides and a moderate increase in high-density lipoprotein cholesterol (HDL-C).
Additionally, fenofibrate can lower low-density lipoprotein cholesterol (LDL-C) and total cholesterol, particularly in patients with elevated baseline levels. Its primary role is in managing severe hypertriglyceridemia to reduce the risk of pancreatitis and in treating mixed dyslipidemia, where it helps to improve the overall lipid profile and potentially reduce cardiovascular risk.
Uses
- Treatment of severe hypertriglyceridemia
- Management of mixed dyslipidemia
- Primary hypercholesterolemia (as adjunct therapy)
- Diabetic dyslipidemia
Directions For Use
Take one tablet orally once daily with food, or as directed by your healthcare provider.
Benefits
- Effectively lowers high triglycerides
- Increases "good" HDL cholesterol
- Reduces the risk of pancreatitis
- Improves overall lipid profile
- May reduce cardiovascular events in specific populations
- Generally well-tolerated
Side Effects
- Abdominal pain
- Nausea
- Diarrhea
- Constipation
- Headache
- Back pain
- Elevated liver enzymes
- Gallstones
- Myopathy (muscle pain)
- Pancreatitis (rare)
- Rash
- Fatigue
Safety Measures
- Alcohol - Limit alcohol intake, as it can increase the risk of liver problems and pancreatitis, which are potential side effects of fenofibrate.
- Pregnancy - Consult your doctor. Use only if the potential benefit justifies the potential risk to the fetus, as limited data is available.
- Breastfeeding - Not recommended during breastfeeding due to limited data on excretion into human milk. Consult your doctor.
- Liver - Contraindicated in patients with active liver disease or unexplained persistent liver function abnormalities. Monitor liver function tests regularly.
- Kidney - Contraindicated in patients with severe renal impairment. Dose adjustment is necessary for moderate renal impairment.
- Lung - No specific contraindications or precautions related to lung conditions are generally noted.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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