About
Rosuvastatin/Fenofibrate is a combination lipid-modifying agent specifically formulated to treat mixed dyslipidemia in adult patients who are at high risk for cardiovascular disease. Rosuvastatin, an HMG-CoA reductase inhibitor (statin), primarily functions by reducing the synthesis of cholesterol in the liver, leading to a significant lowering of low-density lipoprotein cholesterol (LDL-C) and triglycerides, while also modestly increasing high-density lipoprotein cholesterol (HDL-C). Fenofibrate, a fibric acid derivative, works by activating peroxisome proliferator-activated receptor alpha (PPARα), which leads to a substantial reduction in triglycerides and an increase in HDL-C. This powerful combination is particularly effective for patients presenting with elevated triglycerides and low HDL-C, alongside elevated LDL-C, providing a comprehensive and synergistic approach to manage complex lipid profiles and reduce atherosclerotic cardiovascular risk.
Uses
- Treatment of mixed dyslipidemia.
- Reduction of elevated LDL-C, total cholesterol, and triglycerides.
- Increase in HDL-C levels.
- Management of dyslipidemia in high-risk cardiovascular patients.
Directions For Use
Take one tablet orally once daily, preferably with food, or as advised by your healthcare provider.
Benefits
- Comprehensive lipid profile improvement.
- Significant reduction in LDL-C and triglycerides.
- Effective increase in HDL-C.
- Reduces risk of cardiovascular events.
- Convenient once-daily dosing.
- Targets multiple lipid abnormalities.
Side Effects
- Muscle pain (myalgia)
- Headache
- Nausea
- Abdominal pain
- Diarrhea
- Constipation
- Fatigue
- Increased liver enzymes
- Pancreatitis (rare)
- Gallstones (rare)
- Rash
- Dizziness
Safety Measures
- Alcohol - Limit alcohol intake as it can increase the risk of liver damage, a potential side effect of statins and fibrates.
- Pregnancy - Contraindicated during pregnancy due to potential for fetal harm; discontinue if pregnancy occurs.
- Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and harm the infant.
- Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases; monitor liver function.
- Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be necessary, and contraindicated in severe cases.
- Lung - Generally safe for use in patients with lung conditions; no specific pulmonary contraindications.
Disclaimer
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