ADVASTAT F TAB

About

Advastat F combines atorvastatin, an HMG-CoA reductase inhibitor, with fenofibrate, a fibric acid derivative, to provide comprehensive management of mixed dyslipidemia. Atorvastatin primarily reduces LDL-cholesterol by inhibiting cholesterol synthesis in the liver and increasing LDL receptor activity. Fenofibrate, on the other hand, activates peroxisome proliferator-activated receptor alpha (PPARα), leading to increased lipolysis and elimination of triglyceride-rich particles from plasma, and also increases HDL-cholesterol synthesis. This dual-action therapy is particularly effective for patients with elevated triglycerides and low HDL-cholesterol, in addition to high LDL-cholesterol, who have not achieved adequate lipid control with monotherapy. The combination targets multiple lipid fractions, offering a more robust approach to reducing cardiovascular risk associated with complex lipid disorders. Close monitoring for potential muscle and liver-related side effects is crucial.

Uses

• Treatment of mixed dyslipidemia.
• Reduction of elevated triglycerides and LDL-cholesterol.
• Increase of HDL-cholesterol levels.
• Management of dyslipidemia in patients at high cardiovascular risk.

Directions For Use

Take one tablet orally once daily, with a meal, as directed by your physician.

Benefits

• Comprehensive reduction of multiple lipid fractions.
• Significantly lowers LDL-cholesterol and triglycerides.
• Effectively increases "good" cholesterol (HDL-C).
• Reduces the risk of cardiovascular events in mixed dyslipidemia.
• Offers a synergistic approach to lipid management.
• Improves overall lipid profile more effectively than monotherapy.

Side Effects

• Muscle pain (myalgia)
• Abdominal pain
• Nausea
• Diarrhea
• Headache
• Elevated liver enzymes
• Pancreatitis (rare)
• Gallstones (rare)
• Fatigue
• Insomnia
• Rash
• Constipation

Safety Measures

• Alcohol - Excessive alcohol intake can increase the risk of liver and muscle problems. Limit consumption.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Use effective contraception.
• Breastfeeding - Contraindicated during breastfeeding as both components may be excreted in milk.
• Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Monitor liver function closely.
• Kidney - Contraindicated in severe renal impairment. Use with caution and dose adjustment in moderate impairment.
• Lung - No specific contraindications or major concerns related to lung conditions.

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