ROSAVE F 5 10S

About

ROSAVE F 5 is a combination medication containing Rosuvastatin (a statin) and Fenofibrate (a fibrate). Rosuvastatin works by inhibiting HMG-CoA reductase, reducing cholesterol synthesis and primarily lowering LDL-C and total cholesterol. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist, primarily reduces elevated triglyceride levels and increases HDL-C. This combination therapy is prescribed for patients with mixed dyslipidemia, where both high cholesterol (especially high LDL-C) and high triglycerides are present, and who have not achieved adequate lipid control with monotherapy. It aims to comprehensively manage lipid profiles to reduce the risk of cardiovascular disease. The "5" indicates the Rosuvastatin strength.

Uses

• Treatment of mixed dyslipidemia.
• Reduction of high LDL-C and triglycerides.
• Increase of HDL-C levels.
• Prevention of cardiovascular events in high-risk patients.

Directions For Use

Take one tablet orally once daily, preferably with a meal, as directed by your physician. Do not crush or chew.

Benefits

• Effectively lowers both cholesterol and triglycerides.
• Increases beneficial HDL-C levels.
• Reduces the overall risk of cardiovascular disease.
• Provides comprehensive lipid management.
• Improves lipid profile in patients with mixed dyslipidemia.
• Offers synergistic action for better outcomes.

Side Effects

• Muscle pain (myalgia)
• Headache
• Nausea
• Abdominal pain
• Diarrhea
• Constipation
• Liver enzyme elevation
• Gallstones (with fibrates)
• Pancreatitis (rare)
• Rash
• Fatigue
• Rhabdomyolysis (rare, severe muscle breakdown)

Safety Measures

• Alcohol - Limit alcohol consumption as it can increase the risk of liver damage, especially with statins and fibrates, and may elevate triglyceride levels.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Use effective contraception.
• Breastfeeding - Contraindicated during breastfeeding as components may pass into breast milk and harm the infant.
• Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Monitor liver function tests regularly.
• Kidney - Contraindicated in severe kidney impairment. Use with caution in moderate impairment; dose adjustment may be necessary.
• Lung - Rarely, statins can cause interstitial lung disease. Report any new or worsening respiratory symptoms to your doctor.

Disclaimer

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